ARI Abstracts
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 ISSN 2522-235X

eCM Meeting Abstracts 2017, Collection 2

Personalised Therapies for Regenerative Medicine 
TERMIS-EU 2017 Conference, Davos, Switzerland

Poster Abstracts ALL POSTER ABSTRACTS (one file)

Poster Session 1

3D Biofabrication - Part 1: Biofabrication Science

P001 3D cell printing technology for precise fabrication of tissue analogues
Geunseon Ahn, Kyung-Hyun Min, Changhwan Kim, Jeong-Seok Lee, Songwan Jin, Won-Soo Yun, Jin-Hyung Shim

P002 Characterization of Poly(Lactic Acid) scaffold synthesized by 3D printing technology
Febe Carolina Vazquez-Vazquez, David Masuoka-Ito, Daniel Chavarria-Bolaños, Marco Antonio Alvarez-Perez

P005 Freeze-drying as a biofabrication method for achieving a controlled microarchitecture within large complex natural biomaterial scaffolds
Claire M Brougham, Tanya J Levingstone, Gerard Cooney, Nian Shen, Thomas C Flanagan, Fergal J O'Brien

P006 Fabrication of thermoresponsive 3D dual hydrogel systems via 3D bioplotting
Nehar Celikkin, Hans Hendrikse, Marco Costantini, Rebecca Cohn, Joan Simo Padial, Alan Rowan, Wojciech Swieszkowski

P007 3D biofabrication of cell-laden gelatin methacrylate hydrogels
Nehar Celikkin, Jakub Jaroszewicz, Wojciech Swieszkowski

P008 Time-dependent 3D printing of chemically crosslinked gelatin hydrogels
Nicola Contessi, Nehar Celikkin, Alicja Kosik, Maria Cristina Tanzi, Silvia Farè, Wojciech Święszkowski

P009 Biofabrication of a breast cancer model
Pedro Costa, Sarah Carter, Jos Malda, Majorie van Duursen

P010 Biofabrication of a perfusable liver model
Pedro Costa, Kerstin Schneeberger, Vivian Lehmann, Jos Malda, Bart Spee 

P011 Combining self-assembly of hierarchical synthetic extracellular matrices with microscale control of bioprinting
Clara Louise Hedegaard, Estelle Collin, Kee Woei Ng, J Rafael Castrejón-Pita, Alvaro Mata

P013 Rheology as a tool for validation of silk fibroin blend for 3D bio-printing
Rok Kocen, Nataša Drnovšek, Ana Gantar, Saša Novak

P014 Production of engineered-islets and their transplantation to cure type 1 Diabetes
Sae Kamitori, Tomomi Sato, Nobuhiko Kojima

P015 Effects of quercetin-functionalized collagen/hydroxyapatite composites for enhancing osteogenic differentiation of bone marrow-derived mesenchymal stem cells
Yeon ji Kook, Jong Ho Park, Ok Kyun Choi, Jae Geun Cha, Jeong Eun Song, Nirmalya Tripathy, Chan Hum Park, Dong Sam Suh, Gilson Khang

P017 Approach for standardized evaluation of printability and structural deformation of extruded bioink filaments
Maarten Blokzijl, Alexandre Ribeiro, Claas Willem Visser, Riccardo Levato, Miguel Dias Castilho, Wim Hennink, Tina Vermonden, Jos Malda

P018 Inhibition of necrosis in multicellular spheroids by improving oxygen deficient conditions of culture medium and spheroid cores
Hirotaka Mihara, Yasuyuki Sakai, Nobuhiko Kojima

P019 3D bioprinting of mechanically robust cell-laden core-shell strands
Pritesh Mistry, Ahmed Aied, Morgan Alexander, Kevin Shakesheff, Andrew Bennett, Jing Yang

P021 Influence of bio-ink properties on viability of printed cells during drop-on-demand bioprinting
Wei Long Ng, Wai Yee Yeong, May Win Naing

P023 A cell-responsive, photocrosslinkable bioink for extrusion bioprinting of 3D hydrogel constructs
Ruben Pereira, Aureliana Sousa, Cristina Barrias, Paulo Bártolo, Pedro Granja

P024 Robocast zirconia toughened alumina scaffolds: processing and human primary osteoblast response
Ana-Maria Stanciuc, Mauro Alini, Marianna Peroglio, Laurent Gremillard

P025 3D bioencapsulated structures using multiple size hydrogel spheres as building blocks by perfusion based layer-by-layer technique
Praveen Sher, R L Reis, N M Neves

P026 Alginate-fibrinogen and -collagen scaffolds for skin tissue engineering
Elena V Solovieva, Stanislav G Rudyak, Anastasiya Yu Teterina, Vladimir S Komlev, Andrey A Panteleyev

P027 A range of gelatin derivatization strategies lead to biofabrication versatility
Jasper Van Hoorick, Peter Gruber4, Marica Markovic, Jan-Philip Zegwaart, Maximilian Tromayer, Jürgen Van Erps, Hugo Thienpont, Aleksandr Ovsianikov, Peter Dubruel, Sandra Van Vlierberghe

P028 Combination of microfluidics and electrohydrodynamics as tools for the development of in situ cell-laden 3D biografts
Lukas Weidenbacher, Afshin Abrishamkar, Anne Géraldine Guex, Markus Rottmar, Katharina Maniura-Weber, René Michel Rossi, Giuseppino Fortunato

P029 Melt Electrospinning Writing for Tissue Engineering
Shavini Wijesuriya, Valeria Annibaldi, Gillian Hendy, Shane Finnegan, Ellen Byrne, Shirley O'Dea, Michael Macguire

P030 3D-cell cultivation of human adipose-derived mesenchymal stem cells via magnetisable nanoparticles
Anne Wolff, Kirsten Peters

P031 Isolation and characterisation of pepsin soluble type II collagen from mammalian and marine tissue sources for cartilage regeneration
Zhuning Wu, Ioannis Skoufos, Anne Mullen, Athina Tzora, Dimitrios Zeugolis

P033 3D inkjet printed branched vascular networks with feature size < 50 μm
Fei Zheng, Jason Wong, Brian Derby

Advanced Materials for Cell and Biologics Delivery

P034 Controlled release of GET peptides for sustained and highly efficient intracellular delivery
Hosam Al-Deen Abu Awwad, Kevin Shakesheff, James Dixon

P035 Microwave synthesis of fluorescent carbon nanoparticles for use in bio-imaging applications
Marwah Alsharif, Frederik Claeyssens

P036 Enhanced loading and controlled delivery of TGF and VEGF with mesoporous calcium phosphates bone substitutes
Janina Moeller-Siegert, Julien Parmentier, Patrice Laquerriere, Ali Ouadi, Olivier Raisslé, Edouard Jallot, Jean-Marie Nedelec, Cathie Vix-Guterl, Karine Anselme

P037 Multifunctional magnetic-responsive hydrogels modulate platelet lysate-derived growth factor release and guide cell fate
Elsa Silva, Pedro Babo, Raquel Costa-Almeida, Rui Domingues, Bárbara Mendes, Elvira Paz, Paulo Freitas, Márcia Rodrigues, Pedro Granja, Manuela Gomes

P038 PDMS-based block copolymers for soft tissue engineering applications
Evaldas Balciunas, Tatjana Kochane, Virginija Bukelskiene, Saulute Budriene, Daiva Baltriukiene

P039 Application of bioactive melatonin in anticancer therapies: new therapeutic approaches from nutrition to nanomedicine
Enrico Catalano

P040 Biomimetic apatite coating directs endothelial and smooth muscle cell fate as a polymer-free carrier for drug eluting stent
Cen Chen, Dandan Luo, Shichao Ruan, Ya Hao, In-Seop Lee

P041 Non-invasive assessment of mesenchymal stem cells proliferation on micro-structured polyurethane-based fiber scaffolds and evaluation of the fibre orientation effect on cells differentiation
Carla Divieto, Irene Carmagnola, Deyssy Patrucco, Monica Boffito, Alessia Demichelis, Stefano Pavarelli, Gianluca Ciardelli, Maria Paola Sassi

P043 Electrospun scaffolds with potential application in skin wound healing and drug delivery
Annesi Giacaman, Vincenzo Taresco, Ioanna Styliari, Inchira Aldala, Cameron Alexander, Felicity Rose, David Pritchard

P044 Salivary gland radioprotection and functional regeneration via nanotechnology-based protein therapy: A step closer towards clinical translation and personalization?
Alejandra C Fernández, Constanza L Jiménez, Ziyad S Haidar

P045 Formulation and physico-chemical characterization of chitosan-hyaluronan-coated solid lipid nanocapsules for the targeted and release-controlled delivery of paclitaxel
Ziyad S Haidar, Manuel Varas-Godoy, Javier Campos

P049 3D-printing materials and medical coatings - a biocompatibility evaluation
Fabian König, Barbara Steinl, Eike Petersen, Christian Hagl, Nikolaus Thierfelder

P050 Human pluripotent stem cells culture on growth factor-immobilized surface under feeder-free and xeno-free conditions
Meng-Pei Li, Hsing-Fen Li, Akon Higuchi

P054 A new technology for standardized separation and concentration of SVF cells during liposuction
Inge Matthiesen

P055 Osteostimulative collagen nanofleeces to support bone regeneration
Javorina Milosevic, Claudia Heine, Sadat Hasan, Julia Tews, Timothy Ganey, Hans-Jörg Meisel

P057 Silica nano-carrier as a sustained delivery system of GDF5 and TGF-β1 for intervertebral disc regenerative medicine
Nina Henry, Johann Clouet, Thomas Cordonnier, Franck Boury, Jean Le Bideau, Catherine LeE Visage, Jérôme Guicheux

P058 Investigation of the use of bioinspired, star-shaped polypeptides to enhance delivery of stem cells and regenerative proteins to the ischaemic myocardium
Joanne O'Dwyer, Robert Murphy, Andreas Heise, Garry Duffy, Sally-Ann Cryan

P059 In situ delivery of curcumin to pancreatic islets using prolonged release-type microspheres for the prevention of apoptosis
Shiva Pathak, Shobha Regmi, Dong Ho Ha, Tung Thanh Pham, Tiep Tien Nguyen, Chul Soon Yong, Jong Oh Kim, Jee-Heon Jeong

P060 Functional improvement on erectile and ejaculatory in a spinal cord injury after mesenchymal stem cell implantations
Ahmad Jabir Rahyussalim

P061 Study on photo-patterning gelatin scaffold to mesenchymal stem cell growth
Ahmad Jabir Rahyussalim

P062 Controlling GDF6 delivery via PLGA microspheres to direct adipose-derived stem cell differentiation for intervertebral disc regeneration
Tom Hodgkinson, Lisa White, Kevin Shakesheff, Judith Hoyland, Stephen Richardson

P063 Micromolding method to prepare mesenchymal stem cells-containing alginate particles for intra-articular injection in osteoarthritis
Audrey Smith, Mélanie Marquis, Claire Vinatier, Anne des Rieux, Denis Renard, Jérôme Guicheux, Catherine Le Visage

P064 Development and characterization of polymer-based nano-complexes for cartilage regeneration
Federica Vecchies, Pasquale Sacco, Davide Porrelli, Ivan Donati, Gianluca Turco, Eleonora Marsich

P065 Disulfide containing microparticles for the delivery of cells and proteins
Grace Walden, Lawrence Farrell, Aram Saeed

P066 Development of self-assembling peptide hydrogels to release triamcinolone acetonide for the management of oesophageal strictures
Victoria Workman, Deepak Kumar, Andrew Smith, Haidong Li, Felicity Rose, Alberto Saiani, Julie Gough

P068 Autologous tissue expansion in a 3d-construct in vitro and in vivo during one single surgical procedure
Said Zeiai, Clara Chamorro, Jinxing Huo, Jöns Hilborn, Magdalena Fossum

P069 Controlled delivery and release of NGF loaded carriers as a potential Alzheimer disease treatment
Neta Zilony, Michal Rosenberg, Liran Holtzman, Hadas Schori, Ester Segal, Orit Shefi

Bioactive-materials for promoting nerve regeneration

P070 Chitosan-based medical device for improving functional recovery after radical prostatectomy: in vitro study
Stefano Geuna, Luisa Muratori, Federica Fregnan, Stefania Raimondo, Matteo Manfredi, Riccardo Bertolo, Francesco Porpiglia

P071 Controlled delivery of recombinant neurotrophic factors from a nerve guidance conduit for enhanced peripheral nerve repair
William Arthur Lackington, Tijna Alekseeva, Fergal O'Brien

P072 A gene-activated guidance conduit for peripheral nerve repair
William Arthur Lackington, Rosanne Raftery, Fergal O'Brien

P073 Biomimetic apatite and activated iridium oxide formed on titanium as a protein carrier to study NSC behaviours
Cen Chen, In-Seop Lee

P076 Collagen-fibrin engineered neural tissue for peripheral nerve regeneration
Christina MAP Schuh, Adam Day, Heinz Redl, James B Phillips

P077 Chitosan degradation products facilitates peripheral nerve regeneration
Yahong Zhao, Yumin Yang, Xin Tang

P078 Combination of hyaluronic acid hydrogel and wharton's jelly-derived mesenchymal stem cells for spinal cord injury repair
Kristyna Zaviskova, Dmitry Tukmachev, Jana Dubisova, Irena Vackova, Julie Bystronova, Romana Sulakova, Martin Pravda, Sarka Kubinova

Bioengineered stem cell niches 

P079 The assesment of expression of ectoderm, mesoderm and endoderm markers in embyoid body-like cell aggregates formed from wharton's jelly mesenchymal stem cells using in regenerative medicine
Soghra Bahmanpour, Fatemeh Rezaei, Tahereh Talaei

P080 Nichoid substrates promote expansion of adult stem cells in the absence of animal-derived components
Barbara Bonandrini, Davide Ricci, Marina Figliuzzi, Roberto Osellame, Giulio Cerullo, Andrea Remuzzi, Manuela Teresa Raimondi

P081 Osteopontin-a and Osteopontin-b splicing variants are produced during BMSCs and HSCs co-culture in an in vitro bone marrow niche model
Davide Confalonieri, Franziska Ehlicke, Heike Walles

P082 Cellular and mechanical components synergistically enhanced ex vivo expansion in human hematopoietic stem/progenitor cells
Yun Gyeong Kang, Jee-Yeong Jeong, Mi Jin Kim, Su-Hyang Kim, Eun Jin Lee, Jung-Woog Shin

P084 Introducing interstitial fluid flow in a bioengineered breast cancer perivascular niche
Alessandro Marturano-Kruik, Michele Maria Nava, Alan Chramiec, Keith Yeager, Luke Hao, Samuel Robinson, Gordana Vunjak-Novakovic, Manuela Teresa Raimondi

P086 Controlled protein environments and patterned electrospinning can form artificial stem cell niches
Thomas Paterson, Dina Fetih, Selina Beal, Martin Santocildes-Romero, Paul Hatton, Ilida Ortega

P087 Biomaterials based modulation of the MSC secretome
Taimoor Hasan Qazi, David J Mooney, Georg N Duda, Sven Geissler

P088 Delivering a proliferative niche for liver repair via KGF-treatment
Omar Qutachi

P090 A SDF-1 tethered 3D ECM –based scaffold improved muscle progenitor cell migration
Sareh Rajabi-Zeleti, Sasan Jalili-Firoozinezhad, Mohammad Kazemi-Ashtiani, Hossein Baharvand

P091 Exploring the potential of the physico-mechanical environment and circadian timing in adult stem cell differentiation
Eve Rogers, Vanja Pekovic-Vaughan, John Hunt

Biomaterial-based treatments for ischemic diseases

P093 A new 3D hybrid zonal scaffold for articular cartilage tissue engineering
Hamza Abu Owida, Cen Lian, Nicola Kuiper, Ying Yang

P094 Enhancement of therapeutic angiogenesis efficacy by combination of plasmid-based PDGF-B gene therapy and adipose tissue-derived stromal cell therapy in mice
Maria Boldyreva, Ekaterina Zubkova, Evgenij Shevchenko, Irina Beloglazova, Pavel Makarevich, Yelena Parfyonova

P095 The investigation of anion emitting cosmetic textile effect on the improvement of blood circulation in rat model
Ho Yun Chung, Dong Hun Choi, Dong Kyu Kim, Eun Jung Oh, Tae Jung Kim, Hyun Mi Kim, Jin Hyun Choi, Han Do Ghim

P096 Novel biomaterial-based approaches for therapeutic angiogenesis
Eseelle Hendow, Caroline Pellet-Many, Richard Day

P098 Enhancing endothelial adhesion and functionality by modifying surfaces for a biomimetic blood contact interface
Anne-Sophie Mertgen, Anne Geraldine Guex, Greta Faccio, Giuseppino Fortunato, René Rossi, Markus Rottmar, Katharina Maniura

P099 Lactate-releasing biomaterials as cardiac repair inducers
Jesús Ordoño, Elise Bouillot, Miguel Angel Mateos-Timoneda, Soledad Pérez-Amodio, Elisabeth Engel

P100 Potential use of decellularised human vein for coronary arterial grafting
Nadiah Sulaiman, Sandro Satta, Saadeh Suleiman, Sarah George, Raimondo Ascione

Bone tissue engineering

P103 Raman spectroscopic analyses of bone-specific matrix quality produced by in vitro cultured jaw periosteal cells (JPCs)
Dorothea Alexander, Eva Brauchle, Daniel Carvajal Berrio, Melanie Rieger, Katja Schenke-Layland, Siegmar Reinert

P104 Development of zinc and strontium based phosphate glass scaffold as a material for bone tissue engineering
Mustafa Alqaysi, Rishma Shah, Jonathan Knowles

P105 Mesoporous bioactive glasses accelerate the scaffolds colonization by preosteoblast cells
Natividad Gómez-Cerezo, Sandra Sánchez-Salcedo, Isabel Izquierdo-Barba, Daniel Arcos, María Vallet-Regí

P106 Protective effects of mechanical stimulation and extremely low frequency pulsed electromagnetic fields in human osteoblast exposure to cigarette smoke extract
Romina Aspera-Werz, Sabrina Ehnert, Daniel Heid, Vrinda Sreekumar, Andreas Nüssler

P109 Fragility fractures treated by minimally invasive plating augmented by IlluminOss® system combined with early weight bearing, the first cases
Niels Berende, Paul Vegt, Jos Vroemen

P110 Thin degradable coatings for optimization of osteointegration associated with simultaneous infection prophylaxis
Anke Bernstein, Norbert P Südkamp, Hermann O Mayr, Peter Krieg, Rainer Gadow, Andreas Killinger, Sophie Burtscher

P114 Behaviour of a new formulation of fixing cement in joint prostheses with osteomyelitis: a rabbit model
Blanca Ibarra, Joaquin García, Galo Azuara, Miguel A Ortega, Ángel Asúnsolo, Mar Fernandez-Gutierrez, Natalio García-Honduvilla, Basilio Dela Torre, Julio San Román, Julia Buján

P115 The use of an injectable scaffold for the reconstruction of critical-size mandibular defects in rabbits
Kurt Busuttil Naudi, Randa Alfotawi, Ashraf Ayoub, Elizabeth Tanner, Matthew Dalby, Jeremy McMahon

P116 Clinical translation of a tissue engineering product for bone healing: Bioprocess design, preclinical studies and human use
Daniel Chaverri, Daniel Vivas, Santiago Gallardo-Villares, Irene Oliver-Vila, Marian Vives, Ana Carreño, Margarita Blanco, Margarita Codinach, José Ramirez, Javier Pinto, Ruth Coll, Màrius Aguirre, Joan García-Lopez, Joaquim Vives, Fernando Granell-Escobar, Salvi Prat

P117 Preparation and properties of stromal cell-derived factor-1-loaded gelatin/nano-hydroxyapatite composite scaffold
Kuo-Yu Chen, Wei-Jun Lian, Chun-Hsu Yao

P118 New strategies for the evaluation of knee osteonecrosis treatments: an in vitro model
Elena Della Bella, Melania Maglio, Elizaveta Kon, Milena Fini

P119 Influence of fiber spacing on mechanical properties of lattice structured titanium bone grafts: A three-dimensional finite element study
Abir Dutta, Kaushik Mukherjee, Santanu Dhara, Sanjay Gupta

P120 Image-based histological evaluation of scaffold-free 3D osteoblast cultures
Sebastian Eggert, Jutta Tuebel, Peter Foehr, Lara A Kuntz, Andreas Obermeier, Carmen Marthen, Christian U Grosse, Rainer Burgkart

P122 Hypoxia-mimicking porous calcium/ phosphate coated silk scaffolds with controllable cobalt ion release for bone tissue engineering
Nesa Fani, Mohammadreza Baghaban Eslaminejad, Jafar Ai

P124 Endothelial progenitor cell response to nanocrystalline silicon substituted hydroxyapatite coated 3D macroporous Ti6Al4V scaffolds with adsorbed VEGF
MJ Feito, D Fernández-Villa, D Pedraza, MC Serrano, H Alfonso, D Monopoli, D Arcos, I Izquierdo-Barba, M Vallet-Regí, MT Portolés

P126 The rapid induction of bone formation by the human recombinant transforming growth factor-β3 in the non-human primate papio ursinus
Carlo Ferretti, Ugo Ripamonti

P127 Stimulation of human embryonic stem cell-derived mesenchymal progenitors cultured on to porous magnetic microcarriers
Ahssad Fiaz, Hossein Bahmaee, Dan Allwood, Frederik Claeyssens

P128 Novel beta titanium alloy Ti36Nb6Ta is a potential material for bone implants
Eva Filova, Jana Dankova, Vera Sovkova, Josef Sepitka, Ludek Joska, Evzen Amler, Matej Daniel

P129 Evaluation of a scaffold-free 3D osteoblast culture using biomechanical loading and histological characterization
Peter Foehr, Sebastian Eggert, Jutta Tübel, Andreas Obermeier, Lara A Kuntz, Carmen Marthen, Belma Saldamli, Christian U Grosse, Rainer Burgkart

P132 Composite microspheres of glucose-crosslinked gelatin and nano-hydroxyapatite in photo-crosslinked poly(trimethylene carbonate) matrices
Mike A Geven, Dirk W Grijpma

P134 Nanoroughness in titanium boost the cells interaction and bone formation
Tamiye Simone Goia, Kalan Bastos Violin, Ana Helena de Almeida Bressiani, Sydney Ferreira Santos

P135 Radiopaque biodegradable polymeric composites for in vivo monitoring of TE products by X-rays imaging
Zaneta Gorecka, Emilia Choinska, Wojciech Swieszkowski

P137 Purification of an osteogenic peptide isolated from marine fish frame and application of the 3D printed polycaprolactone scaffold for bone regeneration
Seong-Yeong Heo, Seok-Chun Ko, Won-Kyo Jung

P138 Differential chemotactic responses in primary and stem cell-derived osteoblasts
Mathew Hollingworth, Morgan Alexander, Martin Ehrbar, Lee Buttery

P141 Spongy scaffold containing dimethyloxallylglycin accelerates angiogenesis and osteogenesis in rat calvarial defect
Shahrbanoo Jahangir, Frough Aazam Sayahpour, Farhad Mostafaei, Samaneh Hosseini, Mohammad Reza Baghaban Eslaminejad

P142 A large animal caprine model for critical mandibular bone defects
Jeffrey Janus, Kasperbauer Jan, Claudia Gutierrez, David Schembri Wismayer, Heidi Lehrke, Yaszemski Michael

P143 Craniofacial bone regeneration with native periosteum: A caprine model
Jeffrey Janus, Jan Kasperbauer, David Schembri Wismayer, Heidi Lehrke, Michael Yaszemski

P145 Single-dose local administration of parathyroid hormone (1-34) with octacalcium phosphate collagen composites enhances bone regeneration in a rodent critical-sized calvarial defect
Fumihiko Kajii, Atsushi Iwai, Hidenori Tanaka, Keiko Matsui, Tadashi Kawai, Shinji Kamakura

P146 The rat femur chamber: development of a new and versatile model for the observation of changes of the microcirculation inside tissue engineering constructs in femoral defects
Andreas Kampmann, Sarah Gniesmer, Felicitas Miller, Sarah Strauss, Claas-Tido Peck, Peter M Vogt, Mathias Wilhelmi, Thomas Aper, Frank Tavassol, Nils-Claudius Gellrich

P147 Enhanced osteogenesis of human mesenchymal stem cells in mesoporous magnesium silicate/polycaprolactone/wheat protein composite scaffolds
Yun Gyeong Kang, Mi Jin Kim, Yanru Wu, Ji Eun Kim, Eun Jin Lee, Jung-Woog Shin

P148 Application of alginate microbeads as a carrier of bone morphogenetic protein-2
Yun Hwan Lee, Byung-Woo Lee, Byung-Il Yoon, Heung-Myong Woo, Byung-Jae Kang

P149 Nanotopographical modification and electrical stimulation on titanium to promote osteogenesis
Juan Shong Khaw, Michele Curioni, Peter Skeldon, Chris Bowen, Sarah Cartmell

P152 The effect of pore size with constant porosity on cell proliferation and mechanical stiffness
Ji Eun Kim, Ji Min Seok, Su Hyang Kim, Yun Gyeong Kang, Yanru Wu, Mi Jin Kim, Eun Jin Lee, Jung-Woog Shin

P154 Cellular responses on polycaprolactone based mesoporous magnesium silicate scaffolds depending on wheat protein ratio and mechanical stimulation
Mijin Kim, Yun Gyeong Kang, Su Hyang Kim, Yan Ru Wu, Ji Eun Kim, Eun Jin Lee, Jung-woog Shin

P156 Integrated experimental-modelling approach for the osteogenic differentiation of umbilical cord blood mesenchymal stem cells for bone tissue engineering applications
Michail Klontzas, Romuald Gyorgy, Margaritis Kostoglou, Nicki Panoskaltsis, Michael Georgiadis, Athanasios Mantalaris

P157 Effective bone regeneration using PCL/HA hybrid microspheres
Tae Ho Kim, Sang Woo Kim, Se Heang Oh, Jin Ho Lee

P158 Development of bone tissue mimetic polymer mesh scaffold via human lung fibroblast-derived ECM and inorganic mineral
Jong Ho Lee, Yong Kwan Noh, Jaehoon Ko, Kwideok Park

P161 Injectable hybrid system for strontium local delivery to promote bone regeneration
Ana Henriques Lourenço, Nuno Neves, Daniela P Vasconcelos, Cláudia Ribeiro-Machado, Meriem Lamghari, Mário A Barbosa, Judite N Barbosa, Cristina C Barrias, Cristina C Ribeiro

P164 Ultrasonic foaming based development of a hetero-macroporous scaffold for bone tissue engineering applications
Somnath Maji, Tarun Agarwal, Tapas Maiti

P167 Balancing bone resorption and overzealous bone growth in lumbar interbody fusion with RhBMP-2 in the sheep model - a question of dose and/or concentration?
Hans Jörg Meisel, Gerlinde Heil, Julia Tews, Christian Hohaus

P168 Histological analysis of bone regeneration with different doses of rhBMP-2 in an ovine lumbar interbody fusion model
Hans Jörg Meisel, Katharina Siegrist, Julia Tews, Johannes Seeger, Christian Hohaus

P169 Liposomal delivery of BMP-2 and bisphosphonates from polymethyl methacrylate (PMMA) bone cements
Genevieve E Melling, Wayne Nishio Ayre, Rachel J Waddington, Sam L Evans, Deborah Mason, Bronwen Evans, James C Birchall, Rhidian Morgan Jones, Stephen P Denyer, Alastair J Sloan

P170 An Injectable, Bioactive Material for Osteoporotic Bone Regeneration
Simona Morochnik, Rikkert Nap, Igal Szleifer, Guillermo Ameer

P171 Quiescence preconditioned human multipotent stromal cells adopt a metabolic profile favorable for enhanced survival under ischemia
Adrien Moya, Nathanaël Larochette, Joseph Paquet, Mickael Deschepper, Morad Bensidhoum, Valentina Izzo, Guido Kroemer, Hervé Petite, Delphine Logeart-Avramoglou

P172 Development of injectable BMP-2 delivery materials using collagen-I based recombinant peptide microspheres
Didem Mumcuoglu, Laura De Miguel, Shorouk Garcia, Eric Farrell, Joachim Nickel, Gerjo van Osch, Sebastiaan Kluijtmans

P173 Preparation and characterization of scaffold from PCL-IGDP-Collagen and PCL-IGDP-Alginate for bone tissue regeneration
Van-Tinh Nguyen, Seock-Chun Ko, Won-Kyo Jung

P174 Sustained release of BMP-2 from porous bead with unique leaf-stacked structure for effective bone regeneration
Ho Yong Kim, June-Ho Byun, Jin Ho Lee, Se Heang Oh

P175 Fabrication and characterization of BMP-2-immobilized guided bone regeneration membrane with leaf-stacked structure
Jin Hyun Park, Ho Yong Kim, Tae Ho Kim, Jin Ho Lee, June-Ho Byun, Se Heang Oh

P176 The effect of borosilicate glasses and glass dissolution products on human adipose stem cells
Miina Ojansivu, Ayush Mishra, Sari Vanhatupa, Jonathan Massera, Susanna Miettinen

P177 Internalization peptides containing C-Terminal domain of Connexin 43 has no osteogenic effect on human bone marrow mesenchymal stem cells in vitro and on bone regeneration in vivo
Bruno Paiva dos Santos, Mathilde Fenelon, Reine Bareille, Joelle Amédée

P179 Novel supercritical CO2 processed composites for bone applications: the road from manufacturing to cell culture and animal experiments
Sanna Pitkänen, Kaarlo Paakinaho, Markus Hannula, Mikko Manninen, Pauli Keränen, Hanna Pihlman, Mikael Morelius, Minna Kellomäki, Outi Vapaavuori, Susanna Miettinen

P180 3D nanocrystalline silicon substituted hydroxyapatite scaffolds with adsorbed VEGF for bone regeneration by promoting angiogenesis and osteogenesis
L Casarrubios, N Gómez-Cerezo, S Sánchez-Salcedo, MC Serrano, MJ Feito, D Arcos, M Vallet-Regí, MT Portolés

P181 Evaluation of the effectiveness of xeno-free media for human MSC osteogenesis in 2D and poly(ε-Caprolactone) scaffolds
Dirar Qassim, Gwendolen Reilly, Helen Colley, Ian Brook

P182 Evaluation of safety and feasibility of novel tissue engineered bone for large segmental bone defects using autologous mesenchymal stem cells
Vrisha Madhuri, Sowmya Ramesh, Balakumar B, Karthikeyan Rajagopalan, Vivek Dutt D, Bibhudutta Sahoo, Sanjay K Chilbule, Suresh Babu, HKS Varma, Francis Fernandez, Annie John, Roshan Livingstone, Sridhar Gibikote, Augustine Thambiah, Vikram Mathews, Alok Srivastava

P183 Generation and differentiation of scaffold-free self-organizing microspheres from different MSC niches: potential in tissue engineering and disease modeling
El Mustapha Haddouti, Frank Schildberg, Caecilia Hilgers, Robert Pflugmacher, Werner Götz, Dieter Christian Wirtz, Christof Burger, Sascha Gravius, Thomas Randau

P185 Bio-activation of poly(ester-urethane) scaffolds to enhance cell recruitment and bone regeneration
Sylvie Changotade, Sophie Frasca, Jean-Marc Collombet, Jean-Jacques Lataillade, Didier Lutomski, Geraldine Rohman

P187 Cross-linked collagen-based scaffolds colonized by mesenchymal stem cells as a potential tool for bone regeneration – in vitro evaluation
Pavla Sauerova, Tereza Kubikova, Zbynek Tonar, Tomas Suchy, Monika Supova, Sarka Ryglova, Margit Zaloudkova, Zbynek Sucharda, Marie Hubalek Kalbacova

P188 Encapsulation and osteogenic differentation of human periodontal ligament fibroblasts in PRP/hydroxyapatite microbeads
Sukran Seker, A Eser Elcin, Y Murat Elcin

P189 Studying the role of sensory innervation on osteogenesis in a microfluidic coculture system comprising sensory neurons and mesenchymal stem cells
Diana Isabel Silva, Bruno Paiva dos Santos, Jacques Leng, Bertrand Garbay, Elisabeth Garanger, Joëlle Amédée, Hugo Oliveira

P190 The influence of ordered 3D printed PLA scaffold microstructurization on rat dental pulp stem cells
Milda Alksnė, Egidijus Šimoliūnas, Miglė Kalvaitytė, Edvinas Skliutas, Povilas Barasa, Daiva Baltriukienė, Virginija Bukelskienė

P191 Improved bioactivity and antibacterial properties by reduced graphene oxide coating
Sirinrath Sirivisoot

P192 Dentine matrix loaded silk-fribroin/gelatin scaffolds direct osteogenesis of bone marrow mesenchymal stem cells
Steven Avery, Paul DeBank, Alastair Sloan, Rachel Waddington

P193 Cigarette smoke exposure impairs differentiation of human mesenchymal stem cells to osteoblasts and down regulates BMP signalling in vitro – Possible role in delayed fracture healing?
Vrinda Sreekumar, Romina Aspera Werz, Julius Strobel, Christian Bahrs, Sabrina Ehnert, Andreas Nüssler

P194 Direct electrical stimulation may promote mesenchymal stem cell proliferation through a pathway that involves reactive oxygen species (ROS)
Kasama Srirussamee, Sahba Mobini, Sarah Cartmell

P195 Nanodiamonds enhance biocompatibility of copolymer scaffolds for bone regeneration
Salwa Suliman, Yang Sun, Anna Finne-Wistrand, Amani O Hamza, Thilo Waag, Tereza Osdal, Anne Christine Johannessen, Doris Steinmüller-Nethl, Anke Krueger, Daniela E Costea, Kamal Mustafa

P196 Development of a novel RGD-coated porous polyurethane scaffold for bone tissue engineering purposes
Asma Tahlawi, Michail Klontzas, Mark Allenby, Manolis Heliotis, Eleftherios Tsiridis, Athanasios Mantalaris

P197 Designating a 3D scaffold by platelet rich plasma/heparin sulfate/hydroxyapatite/zirconia for bone tissue engineering applications
Tahereh Talaei-Khozani, Mona Latifi, Maryam Kabirsalmani, Hossein Mehraban-Jahromi, Mahsa Sani, Mahnmood Sadeghi-Atabadi

P198 Osteogenic programming of human mesenchymal stem cells with highly efficient intracellular delivery of RUNX2
Lalitha Thiagarajan, Hosam Al-Deen Abu Awwad, Kevin M Shakesheff, James E Dixon

P199 Longitudinal monitoring of VEGFR2 and NFĸB activity during the fracture healing after implantation of novel ß tricalcium phosphate scaffoldsin critical size bone defects in transgenic mice
Mersedeh Tohidnezhad, Diana Roch, Tobias Heigl, Nazanin Barahmand Pour Barahmand Pour, Christian Bergmann, Sabine Neuss-Stein, Hans-Christoph Pape, Horst Fischer, Philipp Lichte, Thomas Pufei

P201 3D longitudinal characterization of swelling in Alginate/Hydroxyapatite scaffolds
Gianluca Turco, Francesco Brun, Federica Vecchies, Davide Porrelli, Agostino Accardo, Sergio Paoletti

P202 Generation and finite element simulation of periodic bone scaffolds
Dvina Valainis

P203 The role of molecular mechanisms of the cell attachment and actin cytoskeleton in human adipose stem cell differentiation
Sari Vanhatupa, Laura Hyväri, Miina Ojansivu, Miia Juntunen, Kimmo Kartasalo, Susanna Miettinen

P204 Screening of layered nanosilicates for the osteogenic differentiation of dental follicle stem cells (hDFSCs) for the development of bone regenerative functional biomaterials
Induvahi Veernala, Jyotsnendu Giri

P205 Mechanisms of bone remodelling induced by tissue engineering products composed of mesenchymal stromal cells and natural bone matrices
Daniel Vivas, Alba López-Fernández, Daniel Chaverri, Marta Grau-Vorster, Anna Del Mazo-Barbara, Blanca Reyes, Marta Monguió-Tortajada, Ana Gámez Valero, Francesc E Borràs, Santiago Roura, Cristina Prat-Vidal, Antoni Bayés-Genís, Màrius Aguirre, Roberto Vélez, Irene Oliver-Vila, Joaquim Vives

P206 Osteogenic differentiation of human adipose stem cells in 3D hydrogels
Kaisa Vuornos, Miina Ojansivu, Janne Koivisto, Jenny Parraga Meneses, Nick Walters, Jari Hyttinen, Janne Ihalainen, Minna Kellomäki, Susanna Miettinen

P207 Influence of bone and tooth matrix on the ability of dental pulp and bone barrow mesenchymal stromal cells to orchestrate mineralised tissue repair
Jodie Harrington, Alastair Sloan, Rachel Waddington

P208 Fabrication of hybrid composite scaffolds using 3D bio plotting system for tissue engineering
YuanZhu Xin, JunHee Lee, Young-Yul Kim, Seok-Jo Yang, Mei-Ling Quan, Cho-Rok Jung 

P209 Real-time dynamic fluorescent imaging of cell response to fluid shear stress
Ruikang Xue, Michele Guastamacchia, Kamel Madi, Stephen Webb, Sarah Cartmell

P210 The topographically defined biodegradable nanopatterned patch for acceleration of bone regeneration
Hee Seok Yang, Min Suk Lee, Wan-Geun La

P212 Development of a label-free cell separator for autologous stem cell enrichment for skeletal tissue repair
Aaron Zammit-Wheeler

P213 A novel Mg2+ eluting degradable polymer shows increase in bone cell proliferation and adhesion
Tianhao Zhou, Edward McCarthy, Constantinos Soutis, Sarah Cartmell

P215 Evaluation of silymarin/duck's feet-derived collagen/hydroxyapatite scaffolds for bone tissu regeneration
YooShin Jeon, Hansol Kim

Cardiac tissue engineering

P216 Biofunctionalisation of decellularised porcine mitral valve scaffolds
Sofia Andriopoulou, Lucrezia Morticelli, Dimosthenis Mavrilas, Michael Harder, Andres Hilfiker, Axel Haverich, Sotirios Korossis

P217 The regenerative potential of extracellular vesicles (EVs) from human cardiac-derived adherent proliferating (CardAP) cells
Christien Beez, Meaghan Stolk, Falk Diedrichs, Marion-Renate Haag, Sophie Van Linthout, Martina Seifert

P218 Biomimetic multilayer membrane for new generation blood propulsion systems
Marzia Brunelli, Géraldine Guex, Lukas Weidenbacher, Stephen Ferguson, Renè Rossi, Giuseppino Fortunato

P219 Novel cantilever-based approach for force measurement of 3D engineered cardiac microtissue within a microfluidic platform
Daniela Cruz-Moreira, Emiliano Votta, Alberto Redaelli, Marco Rasponi

P220 Epicardial implantation of cardiac progenitor cell sheets is more promising method for myocardial regeneration than conventional cell injections
Konstantin Dergilev, Zoya Tsokolaeva, Pavel Makarevich, Maria Boldyreva, Irene Beloglazova, Ekaterina Zubkova, Diana Kanevskaya, Yelena Parfyonova

P223 Micro-scale engineered tissues as in vitro cardiac scar-like model
Paola Occhetta, Giuseppe Isu, Giulia Cerino, Chiara Conficconi, Marta Lemme, Emanuele Gaudiello, Roberta Visone, Philipp Oertle, Marija Plodinec, Marco Rasponi, Anna Marsano

P224 Diffraction enhanced imaging computed tomography for monitoring implanted hydrogel cardiac patches by using a synchrotron light source
Mohammad Izadifar, Mark A Webb, Paul Babyn, Daniel Chen, Michael Kelly

P225 Tissue-engineered cardiac microfibers for the treatment of conduction impairment
Hans Keijdener, Thomas Kuenzel, Brend Hoffmann, Rudolf Merkel, Stefan Jockenhoevel, Petra Mela

P226 In vitro fabrication of 3D cardiac tissues with perfusable blood vessels by cell sheets engineering and measurement of the contractile force
Takao Kimura, Hidekazu Sekine, Kazunori Sano, Katsuhisa Matsuura, Shinzirou Umezu, Tatsuya Shimizu

P227 A high-tech bioreactor system for cardiovascular tissue engineering - increasing quality, possibility and efficiency
Fabian König, Christian Hagl, Nikolaus Thierfelder

P228 Increasing quality and safety of biological grafts - a comprehensive evaluation and mapping of the mechanical, structural and biological characteristics of the bovine pericardium
Ramona Hartinger, Nikolaus Thierfelder, Christian Hagl, Fabian König

P229 Engineering the microenvironment niche of human BM-derived MSC spheroids for enhanced cardiomyogenesis
Jyotsna Joshi, Chandra Kothapalli

P230 Semi-automatic quality control of decellularized human pulmonary roots
Artemis Kouvaka, Michele Marino, Panagiotis Kalozoumis, Lucrezia Morticelli, Serghei Cebotari, Stefan Jockenhövel, Petra Mela, Gino Gerosa, Paola Aguiari, Laura Iop, Axel Haverich, Andres Hilfiker, Michael Harder, Sotiris Korossis

P231 hPSC differentiation into cardiomyocytes cultured on biomaterials immobilized nanosegments (ECMs and oligopeptides)
Cheng Hui Liu

P232 Elimination of residual iPS cells in bioengineered cardiac cell sheets using Dinaciclib
Katsuhisa Matsuura, Khaled Alsayegh, Hidekazu Sekine, Tatsuya Shimizu

P233 Cardiac progenitor cell mechanoresponse in 3D fibrin hydrogels
Arianna Mauretti, Noortje AM Bax, Marie Josè Goumans, Cecilia Sahlgren, Carlijn Bouten

P234 Differentiation of mesenchymal stem cells on fibrin assemblies with immobilized growth factors
Jana Musilkova, Elena Filova, Ondrej Kaplan, Marie Markova, Eduard Brynda, Lucie Bacakova

P235 Contribution of heart extracellular matrix bioscaffolds to disclose the mechanic dynamics behind cardiac pathologies
Ana Rubina Perestrelo, Jorge Oliver de la Cruz, Guido Caluori, Stefania Pagliari, Vladimír Vinarský, Víta ŽAmpachová, Vladimír Horváth, Martin Pešl, Petr Skládal, Diana S Nascimento, Perpétua Pinto-do-Ó, Giancarlo Forte

P236 Tissue adaptation in human saphenous veins cultured ex-vivo in a bioreactor enabling the full-mimicking of coronary-like by pass grafting hemodynamic conditions
Marco Piola, Matthijs Ruiter, Riccardo Vismara, Marco Agrifoglio, Marco Zanobini, Maurizio Pesce, Gianfranco Beniamino Fiore, Monica Soncini

P238 A medium-throughput microfluidic platform for the generation and functional assessment of engineered cardiac microtissues
Roberta Visone, Paola Occhetta, Marco Rasponi

P239 Oxygen-controlled double-compartment culture system for investigating the tissue response induced by different adventitial hypoxic conditions in saphenous vein grafts
Simona Seminati, Marco Piola, Matthijs Ruiter, Maurizio Pesce, Gianfranco Beniamino Fiore, Monica Soncini

P240 Engineering of vascularized tubular myocardial tissues in vitro by using cell technology
Shogo Shimizu, Hidekazu Sekine, Kazunori Sano, Katsuhisa Matsuura, Eiji Kobayashi, Shinjiro Umezu, Tatsuya Shimizu

P241 Well-defined conjugated materials for the engineering of electroactive tissues
Christopher Spicer, Marsilea Booth, Damia Mawad, Astrid Armgarth, Christian Nielsen, Kaja Ritzau-Reid, Molly Stevens

P242 Measurement of the contractile force of the stacked hiPSC-CMs cell sheets on the fibrin-gel
Hiroaki Takahashi, Katsuhisa Sakaguchi, Daisuke Sasaki, Katsuhisa Matsuura, Tatsuya Shimizu Mitsuo Umezu

P243 Where to go in cardiovascular research? A comprehensive evaluation of different tissue engineering and regenerative approaches
Nikolaus Thierfelder, Jang-Sun Lee, Matthias Helm, Francisco Yniguez, Barbara Steinl, Deon Bezuidenhout, Christian Hagl, Fabian König

P245 A novel bioreactor chamber combining interstitial perfusion and electrical stimulation for culturing 3D cardiac constructs allowing non-invasive maturation monitoring and testing
Roberta Visone, Giuseppe Talò, Silvia Lopa, Marco Rasponi, Matteo Moretti

P246 New pu-based scaffold for 3D-mimicking model of engineered cardiac tissue
Federico Vozzi, Manuela Cabiati, Silvia Del Ry, Claudio Domenici, Mara Brancaccio, Nicoletta Vitale, Federica Logrand, Claudia Cicione, Manuele Gori, Alberto Rainer, Monica Boffito, Susanna Sartori, Gianluca Ciardelli

P247 Pathophysiological mimicking in-vitro model of young and aged pu-based scaffold for
cardiac aging studies
Federico Vozzi, Manuela Cabiati, Silvia Del Ry, Claudio Domenici, Mara Brancaccio, Nicoletta Vitale, Federica Logrand, Arti Ahluwalia, Irene Carmagnola, Susanna Sartori, Gianluca Ciardelli

P248 Development of xenogeneic, self-organizing small-caliber vascular grafts
Masashi Yamanami, Takanori Kawasaki, Daisuke Kami, Taiji Watanabe, Keiichi Kanda, Satoshi Gojo, Hitoshi Yaku

Cell-based therapies for cartilage repair 

P249 Si-HPMC/Si-Chitosan hybrid hydrogel for cartilage regenerative medicine: from in vitro to in vivo assessments in nude mice and canine model of osteochondral defects
Cécile Boyer, Julie Lesoeur, Claire Vinatier, Gildas Réthoré, Pierre Barreau, Marion Fusellier, Olivier Geffroy, Pierre Weiss, Olivier Gauthier, Jérôme Guicheux

P250 The fate of meniscus-implants - is their clinical performance dependent on the grade of degradation?
Christoph Brochhausen, David Grevenstein, Andreas Mamilos, Friedrich Barsch, C James Kirkpatrick

P251 Infant chondrocytes from polydactyly patients as a new cell source for cartilage engineering
Emma Cavalli, Matthias Hertl, Anja Gerstenberg, Daniel Weber, Matthias Steinwachs, Marcy Zenobi-Wong

P253 Arthroscopic airbrushing for cell-based treatment of knee cartilage defects - a preclinical in vitro study
Koen Dijkstra, Lucienne Vonk, Daniël Saris

P254 Evaluation of cartilage regeneration strategies in an osteochondral ex vivo cartilage defect model: Effect of cell type and oxygen concentration
Franziska Ehlicke, Alexa Buss, Andrea Schwab, Heike Walles

P255 Effect of spatial PTHrP signalling gradients on human mesenchymal stem cell chondrogenesis and hypertrophy
Niamh Fahy, Oliver Gardner, Mauro Alini, Martin Stoddart

P256 A model system to test tissue engineering approaches for intervertebral disc regeneration under cyclic compressive loading
Rayan Fairag, Derek Rosenzweig, Janet Moir, Michael Weber, Lisbet Haglund

P257 Genetical modified equine mesenchymal stem cells for osteoarthritis treatment
Simone Gabner, Juraj Hlavaty, Reinhart Ertl, Karsten Velde, Matthias Renner, Florien Jenner, Monika Egerbacher

P258 The effect of conditioned medium from human Adipose-derived Stem Cells on Chondrocytes in vitro
Chiara Giannasi, Stefania Niada, Anna Teresa Brini

P259 Development of a one-stage cell therapy for meniscus regeneration using a combination of meniscus cells, mesenchymal stromal cells and the collagen meniscus implant®
Michella Hagmeijer, Daniel Saris, Lucienne Vonk

P260 Study of the effect of synovial fluid and synovial fibroblasts from patients with OA on the healthy knee joint cartilage and influence of human mesenchymal stem cells on the process of regeneration - in vitro studies
Denisa Harvanová, Timea Špaková, Jana Plšíková, Marek Lacko, Vladimír Filip, Ján Kepic, Teodor Kluka, Ján Rosocha

P261Chondrogenesis study in rabbit cartilage cells using gellan-gum/silk-microfiber hybrid scaffolds
Choi Ilnam, Hansol Kim

P262 BMP signaling in chondrocyte differentiation of embryonic stem cells
Witchayapon Kamprom, Christropher Smith, Nicola Bates, Susan Kimber

P263 Regenerative tissue after matrix-associated chondrocyte implantation has better quality using amplified chondrocytes compared to synovial derived stem cells in a rabbit model with short-term follow-up
Eva Johanna Kubosch, Anke Bernstein, Justyna Kowal, Norbert P Südkamp, Hagen Schmal

P264 Inhibiting paracrine senescence prevents mesenchymal stem cell deterioration
Johannes Lehmann, Danai Chatzivasileiou, Natasja Franceschini, Roberto Narcisi, Derk ten Berge, Gerjo van Osch

P265 Observe limb development to improve cartilage tissue engineering: selecting chondroprogenitor cells from adult MSCs by using TWIST1 expression
Roberto Narcisi, Mairéad A Cleary, Anna Albiero, Laurie MG de Kroon, Wendy JLM Koevoet, Simona Gasparini, Pieter AJ Brama, Gerjo JVM van Osch

P266 An animal study evaluating the appropriate cell source for autologous meniscus treatment in an early osteoarthritis situation – a comparison between mesenchymal stem cells and meniscal cells
Johannes Zellner, Girish Pattappa, Matthias Koch, Christian Pfeifer, Michael Mueller, Richard Kujat, Michael Nerlich, Peter Angele

P267 Preparation of in vitro model of osteoarthritis mediated by pro-infalammatory cytokines activated synovial fibroblasts for analysis of therapeutic potential of mesenchymal stem cells
Jana Plsikova, Timea Spakova, Denisa Harvanova, Robert Cellar, Rastislav Sepitka, Teodor Kluka, Karol Koval, Jan Rosocha

P268 Donor variability of ovine mesenchymal stem cell differentiation potential -clinical implications for cell therapies
Eatelaf Mutheffer, Yvonne Reinwald, Katie Bardsley, Alicia El Haj

P269 Influence of the addition of BMP2, BMP6, TGFβ1, TGFβ3 and PTHrP and their combinations on chondrogenesis of stem cells
Sandra Schneider, Ralph Tomys, Sonia Tellado Font, Martijn van Griensven, Elizabeth Rosado Balmayor

P270 Novel markers for quality control of cell-therapeutic approaches to show the cell fate of annulus fibrosus and nucleus pulposus cells from human intervertebral disc
Ann-Kathrin Schubert, Jeske J Smink, Aldemar A Hegewald, Michael Sittinger, Jochen Ringe

P271 The efficacy of intra-articular PRP injection following the microfracture technique or local adherent application of adipose-derived stem cells for the treatment of articular cartilage lesions in a rabbit model
Timea Spakova, Judita Amrichova, Jana Plsikova, Denisa Harvanova, Marek Lacko, Lucia Frohlichova, Slavomir Hornak, Valent Ledecky, Jan Rosocha

P272 Clinical efficacy of in vitro propagated adipose tissue-derived mesenchymal stem cells (AT-MSC) in the treatment of knee osteoarthritis
Dusko Spasovski, Vesna Spasovski, Zoran Bascarevic, Maja Stojiljkovic, Misa Vreca, Marina Andjelkovic, Sonja Pavlovic

P273 MSC-Derived extracellular vesicles stimulate cartilage regeneration and modulate inflammatory responses
Lucienne Vonk, Sanne van Dooremalen, Paul Coffer, Daniel Saris, Magdalena Lorenowicz

P274 Development of a mesenchymal stem cell-based aggregate reinforced by fiberized collagen fibrils for soft tissue repair
Masashi Yamazaki, Kei Oya, Manabu Numao, Hiromichi Fujie

Cell-matrix interactions: innovative 3D hydrogel models for studying and directing stem cell fate

P275 Fast screening method for cell recruitment into growth factor modified PEG-hydrogel
Yannick Devaud, Matthias Lutolf, Vincent Milleret, Martin Ehrbar

P276 Hydrogel matrix stiffness regulates the phenotype of glioblastoma cells
I-Chi Lee, Yung-Chiang Liu, Pin-Yuan Chen

P277 Tuning collagen hydrogel stiffness to enhance the regenerative phenotype of adipose stem cells for peripheral nerve repair
Caitriona O'Rourke, Melissa L D Rayner, Paul J Kingham, James B Phillips

P278 Stem cell signaling in 3D environments: hydrogels vs cryogels
Taimoor Hasan Qazi, Georg Duda, Sven Geissler

P279 Bone marrow mesenchymal stem cells actively participate in the recruitment of murine hematopoietic stem cells in bioengineered minimalistic bone marrows
Queralt Vallmajo-Martin, Matthias Lutolf, Martin Ehrbar

P280 Sequential synthesis of modular poly(ethylene glycol)–peptide hydrogels for controlling stiffness, degradability and biomolecule presentation in 3D artificial stem cell niches
Tracy Yu, Nick J Walters, Oommen Podiyan Oommen, Ricardo MP da Silva, Jöns Hilborn, Susanna Miettinen, Eileen Gentleman

Enabling In situ Extracellular and Elastic Matrix Regenerative Repair

P282 Long term human skin graft: gold standard model formimic constructs and its capability to react after pressure mechanicalstimulation
Andrés A Maldonado, Lara Cristóbal, Miguel A Ortega, Ángel Asúnsolo, Beatriz Romero, Julia Buján, Natalio García-Honduvilla

P283 Local growth hormone therapy on a human skin mouse model produce ulcer healing after
Miguel A Ortega, Lara Cristóbal, Nerea De los Reyes, Natalio García-Honduvilla, Julia Buján, Andrés A Maldonado

P284 Extracellular matrix (ECM) homeostasis in cultures of non-epithelial vaginal cells (NEVCS) from mice with and without pelvic organ prolapse (POP)
Margot Damaser, Slater Jameson, Ganesh Swaminathan, Shataakshi Dahal, Mei Kuang, Bruna Couri, Anna Rietsch, Anand Ramamurthi

P285 Vascular grafts for in situ tissue engineering based on elastin-like recombinamers
Alicia Fernández-Colino, Frederic Wolf, Hans Keijdener, Israel González de Torre, Schmitz-Rode Thomas, Stephan Jockenhoevel, José Carlos Rodríguez-Cabello, Petra Mela

P286 Antibody-based targeting of matrix-regenerative nanoparticles for abdominal aortic aneurysm wall repair in a rat model
Jonathan Fox, Brenton Jennewine, Anand Ramamurthi

P287 Matrix regenerative immuno-nanoparticles to improve the lung tumor microenvironment
Dhruv Seshadri, Anand Ramamurthi

P288 Superior elastic matrix regenerative properties of bone marrow mesenchymal stem cell-derived smooth muscle cells are maintained in a 3D collagenous milieu
Shataakshi Dahal, Anand Ramamurthi

Engineering functional in vitro microenvironments

P289 Development of humanised 3D liver metastasis of pancreatic origin: the role of tissute-specific exctracellular matrix in tumor progression and chemoresistance
Walid Al-Akkad, Pilar Nuñez, Domenico Tamburrino, Luca Frenguelli, Gabriele Spoletini, Vessela Vassileva, Reena Ravikuma, Andrea Telese, Andrew Hall, Stephen Pereira, Giuseppe Fusai, Massimo Pinzani, Krista Rombouts, Giuseppe Mazza

P290 Engineered 3D vascularized skeletal muscle environment inducing the muscle-specificity of the endothelium
Simone Bersini, Mara Gilardi, Stefano Ugolini, Veronica Sansoni, Giuseppe Talò, Silvia Perego, Monica Soncini, Marco Vanoni, Giovanni Lombardi, Matteo Moretti

P291 Measuring micro-mechanics of soft biomaterials in physiological conditions
Giorgio Mattei, Ernst Breel, Jakob Pyszkowski

P292 Validation of corneal bioreactor
Patrick Scalise, Brenden Browb, Elizabeth Orwin

P293 Bioluminescence monitored microtissue assembly in a perfused bioreactor
Irene Cano-Torres, Cristina Garrido, Nuria Rubio, Jerónimo Blanco, Elisabet Engel, Miguel Ángel

P294 Improved cell adhesion and proliferation on synthetic star shaped poly(D,L-Lactide)-b-Gelatin - silica hybrid three dimensional scaffolds
Chelladurai Karthikeyan Balavigneswaran, Kiran Yellappa Vajanthri, Arun Kumar Mahanta, Biswajit Ray, Sanjeev Kumar Mahto, Pralay Maiti, Nira Misra

P295 Fibrous scaffolds for soft tissue regeneration
Huizhi Chen, Lay Poh Tan

P296 Comparative evaluation of adipogenesis of human adipose stem cells in microgravity and gravity culture conditions
Erdem Subak, A Eser Elcin, Y Murat Elcin

P297 Towards bone biomimetic in vitro osteocyte models using micro-3D printing
Felicitas Rahel Flohr, Ralph Mülle

P298 Tenogenic phenotype maintenance and trans-differentiation / differentiation using macromolecular crowding and mechanical loading
Diana Gaspar, Dimitrios Zeugolis

P300 An in vitro chondro-osteo-vascular triphasic model of the osteochondral complex
Riccardo Gottardi, Alessandro Pirosa, Peter Alexander, Dario Puppi, Federica Chiellini, Rocky Tuan

P301 An advanced 3D model to study and develop materials for skin wound healing
Chiara Griffoni, Markus Rottmar, Samantha Chan, Katharina Maniura-Weber

P302 Fabrication of a bilayered scaffold comprising gelatin/polycaprolactone nanofiber electrospun on microfibrous eggshell membrane for wound healing applications
Preetam Guha Ray, Pallabi Pal, Santanu Dhara, Piyali Basak, Somenath Roy

P303 The effect of hypoxia and macromolecular crowding on matrix deposition and phenotype maintenance of human adipose derived stem cells
Salomé Guillaumin, Dimitrios Zeugolis

P305 Biochemical matrix composition, stiffness and compliance orchestrate multipotent differentiation behaviour of human mesenchymal stem cells
Ricarda Hess, Anna Jäschke, Gabriel Jurado, Dieter Scharnweber

P306 Three-dimensional adipogenic differentiation model using human adipose-derived stem cells
Paul Turner, Bhuvaneswari Gurumurthy, Amol Janorkar

P307 Metabolite-sensing in 3D bioengineered kidney tubules stimulates indoxyl sulfate secretion
Jitske Jansen, Rosalinde Masereeuw

P308 Microenvironmental control of interstitial fluid flow to develop in vitro 3D pancreatic islet model
Yesl Jun, Sang-Hoon Lee, Seok Chung

P309 Electrohydrodynamic printing as a method to micropattern large titanium surfaces
Jan Klemes, Marek Pokorny, Nihal Engin Vrana, Adela Kotzianova, Ondrej Zidek, Gulberk Ozcebe, Camille Dollinger, Vladimir Velebny

P310 Bone tissue engineering: a proof-of-concept to derive physiological relevant tailor-made bone constructs in vitro
Poh Soo Lee, Ricarda Hess, Sandra Rother, Ricardo Bernhardt, Hagen Eckert, Manfred Bobeth, Anja Lode, Gianaurelio Cuniberti, Michael Gelinsky, Dieter Scharnweber

P311 Substrate stiffness greatly affects phenotypes of cells; in-vitro culture of human umbilical vein endothelial cell
Eun Jin Lee, Su Hyang Kim, Yun Gyeong Kang, Yan Ru Wu, Mi Jin Kim, Ji Eun Kim, Jung-woog Shin

P312 Oral epithelial cell responses to dentine matrix coated cultureware
Miguel Angel Martin-Piedra, Fernandez-Valades Ricardo, Michael Milward, Richard Shelton, Paul R Cooper

P313 Three dimensional model of the human periodontal ligament to be used as a middle-throughput test system
Nina Meyer, Franziska Koch, Silvio Valdec, Ronald Jung, Britta Striegel, Stephanie Mathes

P314 Tuning the architecture of 3D collagen-based hydrogel constructs using polyvinylpyrrolidone macromolecules
Wei Long Ng, Wai Yee Yeong, May Win Naing

P315 Cellulose nanowhiskers for skeletal muscle engineering
Naa-Dei Nikoi, John Aplin, Julie Gough

P317 Development of decellularized somatic and multipotent cell culture-derived extracellular matrices for regenerative applications
Mahmut Parmaksiz, A Eser Elcin, Y Murat Elcin

P318 Linking bioreactor technology with optical coherence elastography for characterisation of engineered tissues
Yvonne Reinwald, Pierre Bagnaninchi, Ying Yang, Yanny Baba Ismail, Alicia El Haj

P319 Contraction and alignment of bioengineered anchored fibrin constructs as functional skeletal muscle models
Iwan Vaughan Roberts, Christopher Yusef Leon Valdivieso, Roberto Donno, Francesco Galli, Annalisa Tirella, Giulio Cossu, Nicola Tirelli

P320 Influence of 2D and 3D microenvironments on osteogenic differentiation, stemness and angiogenic factor expression under different oxygen tensions
Esen Sayin, Erkan Türker Baran, Ahmed Elsheikh, Vivek Mudera, Umber Cheema, Vasif Hasirci

P321 Biomimetic three-dimensional cultures in a nanofibrous scaffold promotes the generation of salivary lobular organoids from human clonal salivary gland stem cells
Hyun-Soo Shin, Songyi Lee, Hye Jin Hong, Won-Gun Koh, Jae-Yol Lim

P322 Detrusor bioengineering using compressed collagen, adipose-derived stem cells and smooth muscle cells
Jakub Smolar, Maya Horst, Daniel Eberli

P323 Effect of hyaluronic acids from deep-sea organisms in the reconstitution of islet-like tissues using primary islet cells
Keiji Toya, Makoto Noguchi, Nobuhiko Kojima

P324 Development of laser machined and hydrofluoric acid etched funnel-shaped glass pores to facilitate directed growth of neural networks
Sharlayne Waller, Julian George, Patrick Salter, Martin Booth, Hua Ye, Zhanfeng Cui

P325 Tissue-engineered vascular grafts as in vitro models of vascular disease
Frederic Wolf, Felix Vogt, Nicole Schaaps, Anne Cornelissen, Thomas Schmitz-Rode, Stefan Jockenhövel, Petra Mela

P326 Intracellular modelling of hypoxia-mediated stem cell commitment to proliferation
Bo Zhang, Aidong Yang, Cathy Ye

P327 Dental Pulp Cells Secretome Regulates Endothelial Cell Adhesion and Morphology
Maryam Alizadeh Gharaei, Ying Xue, Kamal Mustafa, Inge Fristad

P328 In vivo performance of a bilayered supramolecular scaffold for in situ vascular tissue engineering
Renee Duijvelshoff, Andrea di Luca, Sylvia Dekker, Serge Sontjens, Henk Janssen, Patricia Dankers, Carlijn Bouten

P329 First successful in vivo application of a novel regenerative stent device
Renee Duijvelshoff, Maria Cabrera, Bart Sanders, Carlijn Bouten

P331 Proceedings towards the generation of a three-layered tissue engineered fibrin based vascular graft
Skadi Lau, Melanie Klingenberg, Thomas Aper, Claudia Schrimpf, Axel Haverich, Mathias Wilhelmi, Ulrike Böer

P334 Convergence of notch signalling pathway and the elastin receptor complex (ERC) in fibrin-based vascular tissue constructs
Khalil Dayekh, Kibret Mequanint

P337 Improving endothelialization of decellularized tissues by Fibrin Layers
Marie Steinerova, Elena Filova, Jana Musilkova, Ondrej Kaplan, Martin Plencner, Roman Matejka, Zuzana Riedelova, Tomas Riedel, Johanka Kucerova, Eduard Brynda, Lucie Bacakova

P338 To fabricate an small sized vascular by autologous biotube with PVA
Yu-Chieh Tseng, Ming-Long Yeh

P339 Electrochemically aligned miniaturised tendon organoids for controlled co-culture cellular organisation and crosstalk in a 3D environment
João Coentro, Dimitrios Zeugolis

P340 Vascularization and in vivo biocompatibility of electrospun polycaprolactone fiber mats for rotator cuff tear repair
Sarah Gniesmer, Anna-Lena Hoheisel, Michael Bode, Birgit Glasmacher, Henning Menzel, Andrea Hoffmann, Ralph Brehm, Mathias Wellmann, Frank Tavassol, Nils-Claudius Gellrich, Andreas Kampmann

P341 Biomimetic scaffolds for tendon tissue engineering based on controlled extrusion of dense collagen solutions
Lise Picaut, Léa Trichet, Guillaume Ducourthial, Olivier Ronsin, Marie-Ange Bonnin, Delphine Duprez, Marie-Claire Schanne-Klein, Tristan Baumberger, Gervaise Mosser

P342 Characterisation of collagen type I for biomedical applications
Anna Sorushanova, Ioannis Skoufos, Athina Tzora, Anne Maria Mullen, Dimitrios Zeugolis

P343 Adipose-derived mesenchymal stem cells cultured in tenogenic serum-free medium express tendon-specific markers
Deborah Stanco, Christian Caprara, Gianni Soldati

P344 New insights into tenocyte-immune cell interplay under inflammation in vitro
Meaghan Stolk, Franka Klatte-Schulz, Aysha Schmock, Susann Minkwitz, Britt Wildemann, Martina Seifert

Intervertebral Disc Symposium 2 : Challenges and opportunities in annulus fibrosus repair

P345 Injectable and self-healing dynamic hydrogel as potential artificial nucleus pulposus for intervertebral disc repair
Adrián Pérez-San Vicente, Marianna Peroglio, Manuela Ernst, Pablo Casuso, Iraida Loinaz, Hans-Jürgen Grande, Mauro Alini, David Eglin, Damien Dupin

P346 Comparison of two AF injury models in organ culture
Daniela A Frauchiger, Samantha CW Chan, Lorin M Benneker, Benjamin Gantenbein

P347 Design and evaluation of electrospun structured biomaterials for Annulus fibrosus regeneration
Maude Gluais, Johann Clouet, Sing Yian Chew, Jérôme Guicheux, Catherine Le Visage

P348 Genipin cross-linked fibrinogen repairs annular defects with restoration of biomechanics in vitro and in vivo
Rose Long, Stephen Ferguson, Stephan Zeiter, Lorin Benneker, Mauro Alini, James Iatridis, Sibylle Grad

Microfactories for tissue engineering” or “Regeneration-on-a-chip”

P349 Generation and characterization of wharton's jelly stem cell-based stromal microtissues for tissue engineering
Daniel Durand-Herrera, Fernando Campos, Boris D Jaimes-Parra, Miguel-Angel Martin-Piedra, Alejandro Vela-Romera, Maria del Carmen Sanchez-Quevedo, Ingrid Garzon, Miguel Alaminos, Victor Carriel

P350 Selective cell adhesion in microchannels: hydrodynamic structures combined with aptamer binding to improve microfluidic cell selection
Elena Bianchi, Chiara Arrigoni, Monica Piergiovanni, Paola Roselli, Matteo De Gennaro, Simone Bersini, Mara Gilardi, Junko Enomoto, Junji Fukuda, Gabriele Dubini, Matteo Moretti

P351 Biomaterials-based microfluidic devices with embedded tridimensional topographical features
David Barata, Elena Provaggi, Pamela Habibovic

P352 Biofabrication of a stenotic vessel model
Pedro Costa, Elder Linssen, Hugo Albers, Robert Passier, Albert van den Berg, Jos Malda, Andries van der Meer

P353 Biofabrication of perfusable 3D tissue models
Pedro Costa, Gregor Weisgrab, Elder Linssen, Jos Malda

P355 High-throughput production of highly homogeneous bioactive ceramic microparticles using droplet microfluidics
Víctor P Galván, David Barata, Pamela Habibovic

P357 Three-dimensional spheroid culture systems of mesenchymal stem cells for tissue regeneration
Ji-Young Hwang, Yoon Shin Park, Yesl Jun, Sangmee Ahn Jo, Tae-Hee Kim, Gi Jin Kim, Inho Jo, Sang-Hoon Lee

P358 Multi-variate bioreactor with independent or interlinked sensing and actuating mechanisms
Andreas Kaasi, Higor Barreto Campos, Renata Tomaz Quevedo, A.ndré Luiz. Jardini, Paulo Kharmandayan

P359 Cell manufacturability for retina epithelial pigment cells derived from hiPS cells
Masahiro Kino-Oka

P360 Miniaturized high-content imaging (HCI) of 3D-cultured cell microarrays for mechanistic toxicity assessment
Pranav Joshi, Akshata Datar, Kyeong-Nam Yu, Alexander Roth, Moo-Yeal Lee

P362 Cancer cell tracking using dendrimer nanoparticles uptake in a microfluidic platform
Mariana Carvalho, Raquel Maia, Joana Silva-Correia, Bruno Costa, Rui Reis, Miguel Oliveira

P363 Next-generation microfluidic platforms for patterning stem cells
Pinak Samal, Nicolas Rivron, Clemens van Blitterswijk, Roman Truckenmüller, Stefan Giselbrecht

P364 Modelling of 3D spatially controlled compartmentalized tissues in microfluidics
Giovanni Stefano Ugolini, Roberta Visone, Alberto Redaelli, Matteo Moretti, Marco Rasponi

Multiscale Mechanobiology in Tissue Engineering

P365 Breaking balance of cellular forces within the expanding Madin-Darby canine kidney (MDCK) cell monolayer by hepatocyte growth factor (HGF) gradient
Hwanseok Jang, Chan Young Park, Yongdoo Park

New trends in CNS regeneration and treatment

P368 A hybrid electrospun titanium or zinc oxide-polyurethane as a material for self-cleaning shunt catheters
Davide Erbogasto, Richard Black

P370 The effect repeated intrathecal and intramuscular application of mesenchymal stem cells and their secretome in the treatment of amyotrophic lateral sclerosis
Monika Šeneklová, Serhiy Forostyak, Yuriy Petrenko, Pavla Jendelová

P372 Evaluation of adipose stem cells (ASCs) impact on central nervous system in vitro
Aleksandra Zolocinska, Zygmunt Pojda

Novel Strategies for Tissue Vascularization

P373 Generation of vascularized constructs for transplantation in large animal models
Birgit Andree, Nina Friese, Axel Haverich, Andres Hilfiker

P374 Urokinase system and extracellular matrix produced by cells are crucial for robust functional vascular network formation by cooperation of adipose stromal cells and endothelial cells
Irina Beloglazova, Ekaterina Zubkova, Victoria Stepanova, Konstantin Dergilev, Natalia Koptelova,
Pyotr Tyurin-Kuzmin, Yelena Parfyonova

P375 Cardiac bone marrow-derived cell-based therapy associated with scaffold for heart regeneration
Inês Borrego, Aurélien Frobert, Jérémy Valentin, Guillaume Ajalbert, Valérie Roth, Benoît Fellay, Stéphane Cook, Marie-Noelle Giraud

P376 Short-term delivery of fibrin-bound VEGF protein in osteogenic grafts: increased vascularization with efficient bone formation
Maximilian Burger, Andrea Grosso, Alexander Lunger, Priscilla S Briquez, Jeffrey A Hubbell, Dirk Schäfer, Andrea Banfi, Nunzia Di Maggio

P378 Controlled in vivo angiogenesis in specifically biofunctionalized elastin-like recombinamer-based scaffolds
Israel Gonzalez De Torre, Sebastian Staubli, Giulia Cerino, Matilde Alonso, Daniel Oertli, Friedrich Eckstein, Katharina Glatz, José Carlos Rodríguez Cabello, Anna Marsano

P379 Functionalising a collagen-based scaffold with on-demand drug delivery for diabetic wound healing
Cathal Kearney, Ronaldo do Amaral, Renuka Sitram, Fergal O'Brien

P381 Human bone marrow mesenchymal stromal cells, adipose tissue-derived stromal cells and bone marrow mononuclear fraction improve wound healing in diabetic rat model
Zuzana Kočí, Robert Bém, Michal Dubský, Andrea Němcová, Karolína Turnovcová, Alexandra Jirkovská, Eva Syková, Šárka Kubinová

P382 Electrospun yarns for vascularization applications in tissue engineering
Magnus Kruse, Franziska Kreimendahl, Thomas Gries, Stefan Jockenhoevel

P383 Developmentand characterisation of a composite skin construct with electrospun membrane andmicrochannel hydrogel 
Xuxin Lim, Julian Dye, Hua Ye, Zhanfeng Cui

P384 Alginate/Gelatin hydrogels to coat porous tubular scaffolds for vascular tissue engineering
Claudia Tresoldi, Daniela Pacheco, Elisa Formenti, Roberta Gentilini, Sara Mantero, Paola Petrini

P385 Human fibroblast-derived matrix facilitates vasculogenesis in 3D environment and enhances skin wound healing
Kwideok Park, Ping Du, Sang Soo Ha

P386 Intestine re-endothelialisation for whole organ bioengineering
Alessandro Filippo Pellegata, Alfonso Maria Tedeschi, Dipa Natarajan, Asllan Gjinovci, Justina Then, Luca Urbani, Paolo De Coppi

P387 Electrospinning of bi-layered vascular grafts resembling the architecture of the natural blood vessel
Iris Pennings, Tomasz Jungst, Jürgen Groll, Toine Rosenberg, Debby Gawlitta

P388 Development of novel bioreactor system with pulsatile-pressurization for tissue fabrication
Kazunori Sano, Hidekazu Sekine, Kenji Izumi, Eiji Kobayashi, Tatsuya Shimizu

P389 Study of the effect of collagenous microcarriers on the vasculogenic potential of endothelial cells and their use in perfusion bioreactors
Melva Suarez Muñoz, Gudrun Dandekar, Heike Walles

P390 Micro-computed tomography techniques applied in the evaluation of polymeric and composite bone scaffolds – in vivo study
Karol Szlazak, Jakub Jaroszewicz, Joanna Idaszek, Tomasz Debsk, Zygmunt Pojda, Wojciech Swieszkowski

P391 Vascularization of human bio-artificial muscles
Dacha Gholobova, Melanie Gerard, Linda Desender, Gilles Carpentier, Maurilio Sampaolesi, Herman Vandenburgh, Lieven Thorrez

P392 Fabrication of a human transplantable vascular bed using re-endothelialized acellular porcine intestine
Yusuke Tobe, Katsuhisa Sakaguchi, Kazunori Sano, Hidekazu Sekine, Tatsuya Shimizu, Eiji Kobayashi, Mitsuo Umezu

P393 The effect of platelet rich plasma on the blood vessels volume of CCl4-induced hepatotoxic model
Zahra Vojdani, Afsaneh Mafi, Farzaneh Dehghani, Tahereh Talaei-Khozani, Abbas Moghadam, Ali Noorafshan

Regenerative Medicine for Incontinence

P394 Reconstruction of rat bladder with human amniotic membrane graft
Dimitri Barski, Holger Gerullis, Gabriella Varga, Mihaly Boros, Isabel Pintelon, Jean-Pierre Timmermans, Thomas Otto

P396 Let's mesh it better: Advanced cell based gynaecological care for women with pelvic organ prolapse (pop)
Shayanti Mukherjee, Shanti Gurung, Saeedeh Darzi, Stuart Emmerson, Fiona Cousins, Anna Rosamilia, Jerome Werkmeister, Caroline Gargett

P397 The use of pooled human platelet lysate for isolation and ex vivo expansion of skeletal myoblasts for clinical use
Samir Ranjitkar, Alana Miranda Pinheiro, Aaron Boyer, Vladimir Zachar, Cristian Pablo Pennisi

P398 Sensitivity of different cell types towards paclitaxel
Henrike Rebl, Wolfgang Kram, Matthias Schnabelrauch, Oliver Hakenberg, Barbara Nebe

P399 Autophagy is needed during the differentiation of adipose derived stem cells to functional smooth muscle cells for use in bladder engineering
Souzan Salemi, Tullio Sulser, Daniel Eberli

P400 Synergistic effects of combining undifferentiated adult stem cells and differentiated cells for the engineering of functional bladder smooth muscle tissue
Souzan Salemi, Daniel Keller, Markus Rottmar, Tullio Sulser, Daniel Eberli

Regenerative medicine in the aging musculoskeletal system

P401 Bone marrow stromal cells from elderly patients undergoing hip replacement surgeries: an in vitro model for impaired bone healing
Laura Ogrin, Alexandra-Larissa Stetco, Heinz Redl, Darja Marolt

P403 Identification of differential GDF6 signalling responses in subpopulations of human bone marrow and adipose-derived stem cells: implications for intervertebral disc regeneration
Tom Hodgkinson, Ashish Diwan, Judith Hoyland, Stephen Richardson

P404 Radiological evaluation of bone in animals with experimental osteoporosis after implantation of bioceramic granules
Ilze Salma, Janis Locs, Girts Salms

P405 The impact of donor age on the morphology and functional properties of mesenchymal stem cells from adipose tissue
Katarzyna Siennicka, Zygmunt Pojda

P406 Cartilage degeneration affects underlying subchondral bone remodelling
Maryam Tamaddon, Shen-Mao Chen, Alister Hart, Chaozong Liu

P407 The optimal timing of hydrogel injection for treatment of intervertebral disc degeneration: Quantitative analysis based on T1ρ MR imaging
Zhiyu Zhou, Fuxin Wei, Manman Gao, Junxuan Ma, Zemin Ling, Hao Hu, Xuenong Zou

RNA Therapeutics and Gene Delivery for TERM

P408 MicroRNA-132 in bladder wound healing
Xi Liu, Clara Ibel Chamorro, Dongqing Li, Ning Xu Landén, Behnaz Khalilzadeh Binicy, Magdalena Fossum

P409 Upregulation of osteo-related genes and BMP2 secretion in muscle-derived stem cells after mRNA transfection
Wen Zhang, Manish K Anaja, Rodolfo De La Vega Amador, Carsten Rudolph, Christian Pank, Martijn van Griensven, Christopher H Evans, Elizabeth R Balmayor

P410 Delivery of modified BMP-2 plasmid enhances mesenchymal stem cell osteogenesis and critical size defect repair over unmodified BMP-2 plasmid
Rosanne M Raftery, Simon Sperger, Ara Hacobian, Irene Mencia Castano, Gang Chen, Brenton Cavanagh, Caroline M Curtin, Heinz Redl, Fergal J O'Brien

P411 Generation of integration-free iPSC using mRNA delivery
Hye Yeon Choi, Tae-Jin Lee, Seuk Young Song, Gwang-Mo Yang, Jaesur Oh, Jihye Won, Gun-Jae Jeong, Jongpil Kim, Byung-Soo Kim, Ssang-Goo Cho

P412 DNA and RNA editing in exon 26 of DYSF gene for gene-cell therapy of LGMD2B and miyoshi myopathy
Ivan Yakovlev, Roman Deev, Irina Starostina, Valeria Solovyeva, Albert Rizvanov, Artur Isaev

Self-assembling systems for complex tissue engineering

P414 Long term 3D spheroid culture of Huh-7 cells for production of HCV particles
Murielle Dufresne, Bowen Wen, Marie José Fleury, Ulysse Pereira, Isabelle Pezron, Sandrine Castelain, Cécile Legallais

P415 Leukocyte and Platelet-rich Fibrin in Oro-Dental and Maxillo-Facial Surgery: Evidence from Randomized Controlled Clinical Trials
Constanza Jiménez, Francisco Muñoz, Ziyad S Haidar

P417 Metabolic capabilities of a psoriatic skin substitute
Roxane Pouliot, Alexandre Morin

P418 Designing 3D cell niches exploiting peptide self-assembly for TERM applications
Alberto Saiani, Aline Miller

Silk Biomaterials

P421 Micro-computed tomography analysis of tissue engineering scaffolds: How?
Ibrahim Fatih Cengiz, Joaquim Miguel Oliveira, Rui Luís Reis

P422 Bioactive glass / fibroin composite scaffolds for the treatment of osteochondral defects
Natasa Drnovsek, Rok Kocen, Metka Voga, Gregor Murn, Lenart Girandon, Aleksander Recnik, Gregor Majdič, Saša Novak

P423 Differential mechanism of bone differentiation on mulberry and non-mulberry silk
Sourabh Ghosh, Swati Midha

P424 Spider silk nerve implant for reconstruction of peripheral nerves: Schwann cell migration in 15.0cm artificial nerve grafts
Tim Kornfeld, Peter M Vogt, Vesna Bucan, Claas-Tido Peck, Kerstin Reimers, Christine Radtke

P425 Development of silk based angle-ply construct for annulus fibrosus tissue engineering
Bibhas K Bhunia, Manishekhar Kumar, Biman B Mandal

P426 Copper (II)-silk fibroin hybrid flowers with Antibacterial activity and selective cytotoxicity
Banani Kundu, Mohamed Eltohamy, SC Kundu, Hae-Won Kim

P428 Silk fibroin nanofibres in cardiac drug delivery
Miroslava Rysová, Hana Tománková, Dagmar Poláková, Lenka Martinová, Jana Rotková, Jiří Maryška

Tendon pathology and regeneration. Where are we?

P429 Simulated hypergravity induces changes in human tendon-derived cells: from cell morphology to gene expression
Raquel Costa-Almeida, Daniel TO Carvalho, Miguel JS Ferreira, Tamagno Pesqueira, Monica Monici, Jack JWA van Loon, Pedro L Granja, Manuela E Gomes

P430 Biochemical and biomechanical characterization of a novel xenogenic ACL substitute
Vincenzo Guarino, Paolo Fattori, Marietta D'Albore, Stefania Zeppetelli, Luigi Ambrosio, Mauro Fiorini

P431 Comparing two common production methods for platelet-rich plasma and the boosting effect for human anterior cruciate ligamentocytes
Anna M Krismer, Romina Cabra, Rahel May, Sandro Kohl, Sufian S Ahmad, Benjamin Gantenbein

P432 Triggering the activation of activin A type II receptor in human adipose stem cells towards tenogenic commitment using mechanomagnetic stimulation
Ana Gonçalves, Michael Rotherham, Hareklea Markides, Márcia Rodrigues, Rui Reis, Manuela Gomes, Alicia El Haj

P433 Development of an extracellular matrix scaffold for the treatment of tendon injuries
Anthony Grognuz, Pierre-Arnaud Aeberhard, Dominique P Pioletti, Wassim Raffoul, Lee A Applegate

P434 Can collagen matrix composition drive a viscous profibrotic cycle in chronic tendinopathy?
Amro A Hussien, Nina Nydegger, Martin Ehrbar, Jess G Snedeker

P435 Identification of miRNA with a putative role in tendogenic formation of mesenchymal stem cells
Yvonne Roger, Olena Pogozhykh, Sarah Gniesmer, Andreas Kampmann, Andrea Hoffmann

P436 Ciprofloxacin and uremic toxins affect human tenocytes in vitro
Erman Popowski, Benjamin Kohl, Tobias Schneider, Joachim Jankowski, Gundula Schulze-Tanzil

P437 Bevacizumab reduces angiogenesis in a rat tendon defect model
Herbert Tempfer, Nadja Kunkel, Stefanie Korntner, Christine Lehner, Alexandra Kaser- Eichberger, Ludwig Heindl, Falk Schroedl, Andreas Traweger

The immune system in tissue engineering and regenerative medicine

P439 Immunogenicity of glutaraldehyde-fixed porcine heart valves in patients after implantation up to 51 months is induced by both antigenic tissue proteins and the αGal epitope
Ulrike Böer, Falk FR Buettner, Ariane Schridde, Melanie Klingenberg, Samir Sarikouch, Axel Haverich, Mathias Wilhelmi

P440 The number of M2-macrophages do not correlate with fibrosis in peritoneal adhesion formation: an animal study
Christoph Brochhausen, Andreas Mamilos, Volker Schmitt, Constanze Planck, Taufiek Rajab, Friedrich Barsch, Helmut Hierlemann, C James Kirkpatrick

P441 Harnessing bacterial antigens for bone regeneration
Michiel Croes, Willemijn Boot, Moyo Kruyt, Behdad Pouran, Wouter Dhert, F Cumhur Öner, Jacqueline Alblas

P442 The role of inflammation in epimorphic regeneration
Teddy Nelson, Cheng-chen Huang

P444 Porous gelatin/alginate/fucoidan scaffold for anti-inflammatory activity in BV2 cells
Van-Tinh Nguyen, Seock-Chun Ko, Won-Kyo Jung

P445 Macrophages priming towards an alternative activation profile by allogeneic adipose tissue-derived stem cells
Carolina Ferreira, Tircia Santos, Ines Mesquita, Ricardo Silvestre, Rui Reis

P446 Antibody-based tumor clearance and tissue regeneration characters of a Poly(L-lactide) electrospun membrane incorporated with anti-CD40 antibody
Xingzhi Liu, Yanzheng Gu, Huilin Yang, Wenguo Cui, Qin Shi

Tissue engineering as enabling technology for cancer diagnosis and treatment

P447 Cellular interplay of cancer associated fibroblasts in endometrial tumor tissue
Keito Adachi, Takahiro Iwamiya, Masaru Tomita

P451 Polyurethanes: a promising platform for engineering in vitro healthy and pathological tissue models
Monica Boffito, Susanna Sartori, Stefano Calzone, Gianluca Ciardelli

P452 Three-dimensional in vitro neural stem-endothelial cells co-culture model: The recapitulation of neuroblastoma microenvironment for long term drug testing
Phurit Bovornchutichai, Julian George, Xiao Wan, Eric O'Neill, Hua Ye

P453 Polyesterurethanes engineered theranostic nanoparticles for cancer diagnosis and treatment
Clara Mattu, Giulia Brachi, Luca Menichetti, Elia Ranzato, Simona Martinotti, Alessandra Flori, Daniele De Marchi, Cinzia Avigo, Paolo Armanetti, Gianluca Ciardelli

P454 Combining the versatility of polyurethane chemistry and additive manufacturing technologies in the design of engineered in vitro models
Stefano Calzone, Monica Boffito, Choudhury Deepak, May Win Naing, Gianluca Ciardelli

P456 Polyphenols and bioactive glass: a smart couple against cancer
Martina Cazzola, Enrica Vernè, Andrea Cochis, Rita Sorrentino, Barbara Azzimonti, Lia Rimondini, Enrico Prenesti, Sara Ferraris

P457 A hydrogel-based platform for the ex vivo activation and expansion of T cells
Matthew Chin, Eileen Gentleman, Marc-Olivier Coppens, Richard Day

P458 A new gold nanoparticle-based nanosystem for the delivery of anticancer drugs
Alessio Massironi, Francesco Cristofaro, Nora Bloise, Cristina Della Pina, Michele Rossi, Paolo Ferruti, Elisabetta Ranucci, Livia Visai

P459 A goat liver extracellular matrix-based tumor-mimicking environment for mechanobiological study of cervical cancer progression
Joyjyoti Das, Tarun Agarwal, Tapas Maiti

P460 Exploring the role of PCL electrospun matrices on in vitro cell response to chemotherapeutic drug therapies
Vincenzo Guarino, Ines Fasolino, Marica Marrese, Valentina Cirillo, Luigi Ambrosio

P463 Chitosan-based hydrogels as biological inks for fabrication of cellularized 3D-complex structure mimicking living organs
Rossella Laurano, Chiara Tonda-Turo, Monica Boffito, Marina Maria Boido, Valeria Chiono, Gianluca Ciardelli

P464 Layer-by-layer printing of Hep3B human hepatoma cell line for cancer cell migration in 3D
Alexander Roth, Stephen Hong, Yana Sichkar, Kyeong-Nam Yu, Oju Jeon, Eben Alsberg, Moo-Yeal Lee

P465 A phasor approach analysis of multiphoton fluorescence lifetime imaging microscopy measurements to probe the metabolic activity of three-dimensional in vitro disease models
Michael Monaghan, Pirmin Lakner Lakner, Yvonne Moeller, Monilola Olayioye, Katja Schenke-Layland

P466 Metastatic melanoma human 3d models for in vitro evaluation of targeted drugs efficiency
Delphine Morales, Florian Lombart, Agathe Truchot, Pauline Maire, Pascale Vigneron, Murielle Dufresne, Antoine Galmiche, Catherine Lok, Muriel Vayssade

P467 Evaluation of tumor malignant mechanism of pancreatic cancer associated fibroblasts
Yugo Otake, Takahiro Iwamiya, Masaru Tomita

P470 3D bioengineered systems for tissue engineering cancer research
Julio Manuel Rios de la Rosa, Annalisa Tirella

P472 Application of tissue engineering strategies for generating of an in vitro and in vivo model for understanding breast cancer progression and angiogenesis
Annika Weigand, Justus P Beier, Pamela L Strissel, Paul D Dalton, Majida Al-Abboodi, Matthias W Beckmann, Tobias Bäuerle, Reiner Strick, Raymund E Horch, Anja M Boos

Whole-Organ Bioengineering

P474 A multilayered palate substitute generated by tissue engineering. An in vivo evaluation
Miguel-Angel Martin-Piedra, Ingrid Garzon, Boris D Jaimes-Parra, Daniel Durand-Herrera, Fernando Campos, Ricardo Fernandez-Valades-Gamez, Antonio España, Victor Carriel, Ricardo Fernandez-Valades

P476 Development of a perfused organotypic kidney model using decellularized rat kidneys
Iris Fischer, Krithika Hariharan, Petra Reinke, Andreas Kurtz, Harald Stachelscheid

P478 Surface modification of polystyrene for cell adhesion and spreading due to active oxygen exposure
Kazuki Hosoya, Kazunari Takahashi, Kei Oya, Satoru Iwamori

P479 Reconstruction of vascular networks in perfusion culture using a decellularized liver scaffold
Yano Koki, Watanabe Masahumi, Okawa Koki, Sudo Ryo

P481 An automated decellularisation bioreactor for closed-system GMP-compliant manufacture of tissue engineered organs
Toby Proctor, Luca Urbani, Alessandro Pellegata, Benyamin Rahmani, Xenia Charalambous, Farlan Veraitch, Mark Lowdell

P483 Off the shelf collagen graft for urethral reconstruction
Ganesh Vythilingam, Hans M Larsson, Kalitha Pinnagoda, Elif Vardar, Eva -Maria Engelhardt, Rajendrarao C Thambidorai, Tunku Kamarul, Jeffrey A Hubbell, Peter Frey

P484 Suspension culture of hiPSC aggregates under plastic fluid condition
Riku Yamamoto, Masahiro Kino-oka

P485 Effect of the CCL5 releasing fibrin gel for intervertebral disc regeneration
Zhiyu Zhou, Alini Mauro, Grad Sibylle, Zhen Li

Poster Session 2

3D Biofabrication - Part 2: Application of Biofabrication

P486 Clinical application of patient-specific 3D-printed biodegradable scaffolds for maxillary reconstruction
Hyun Ho Han, Hyungseok Lee, Jeong-Seok Lee, Jin-Hyung Shim, Won-Soo Yun, Dong-Woo Cho, Chunghwan Baek, Jong-Won Rhie

P487 A 3D thermo-responsive co-electrospun fibrous scaffold for extended culture and enzyme-free passage of quiescent primary human corneal stromal stem cells
Afnan Aladdad, Laura Sidney, Andrew Hopkinson, Cameron Alexander, Felicity RAJ Rose

P488 Evaluation of 3D hepatic tissue models for bioprinting
Epifania Bono, Stephanie Mathes, Markus Rimann

P489 Melt electrospun written scaffolds as in-vitro platforms for cell culture: the effect of scaffold pore architecture
Kian Eichholz, David Hoey

P492 Combined thermal and fluid flow simulation for the optimization of a 3D-culture bioreactor
Peter Foehr, Veronika Heinrich, Constantin von Deimling, Lara A Kuntz, Andreas Obermeier, Jutta Tübel, Christian U Grosse, Rainer Burgkart

P494 3d printing of an elastic and biodegradable trachea made by water borne polyurethane for tissue engineering and regeneration
Cheng-Tien Hsieh, Kun-Chih Cheng, Shan-hui Hsu

P495 Biocompatibility of polycaprolactone fabricated by three dimensional printing in nasal reconstruction: a experimental study in rabbits
Se Hwan Hwang, Do Hyun Kim, Sung Won Kim

P497 Optimizing Process Parameters for 3D Melt Electrospinning Printing
Cem Balda Dayan, Seyedeh Ferdows Afghah, Burcu Saner Okan, Mehmet Yildiz, Yusuf Menceloglu, Mustafa Culha, Bahattin Koc

P498 3D printing PCL/PPSu polymeric scaffoldsfor wound healing applications
Seyedeh Ferdows Afghah, Cem Balda Dayan, Burcu Saner Okan, Mohib Ullah, Jamal Seyyed Monfared Zanjani, Pinar Akkus, Ozlem Sen, Alpay Taralp, Mehmet Yildiz, Yusuf Menceloglu, Mustafa Cuhla, Bahattin Koc

P500 Formulation and optimization of a VEGF peptide based bioink for skin reconstruction 
Jeong Ok Lim, Jang Soo Suh, Bo Kyung Park, Li Wen Wong, Heon Ju Lee, Mi Sun Hwang

P501 Development of porous nanofibrous 3D scaffold by emulsion electrospinning for skin tissue regeneration
Pallabi Pal, Santanu Dhara

P502 Difference of 3D printed artificial trachea according to additive manufacturing process
Hae Sang Park, Ok Joo Lee, Soo Yeon Jung, Han Su Kim, Jae Hong Park, Ki Nam Park, Yoo Seob Shin, Won Shik Kim, Chan Hum Park

P503 Development of a 3D limbal epithelial crypt using a two photon polymerization system
Elisabetta Prina, Laura Sidney, Maximilian Tromayer, Jonathan Moore, Robert Liska, Marina Bertolin, Claudia Breda, Andrew Hopkinson, Harminder Dua, Stefano Ferrari, Jing Yang, Ricky Wildman, Felicity Rose

P504 Controlling tissue morphogenesis in vitro: fabrication of full thickness human skin equivalent completely formed of cell-assembled ECM
Francesca Rescigno, Costantino Casale, Giorgia Imparato, Francesco Urciuolo, Paolo Antonio Netti

P506 Contact guidance for cardiac tissue engineering using 3D bioprinted gelatin patterned hydrogel
Ajay Tijore, Scott Alexander Irvine, Priyadarshani Mhaisalkar, Vrushali Baisane, Subbu Venkatraman

P507 Hybrid electrospun silk fibroin and polyurethane vascular graft: a semi-degradable vascular access alternative for haemodialysis
Sebastião van Uden, Valentina Catto, Francesco Giovanni Greco, Alberto Cesare Luigi Redaelli, Stefania Adele Riboldi

P508 3D bio-printed artificial skin model for in vitro test
Joo-Yun Won, Heejin Kim, Min Kyoung Kim, Geunseon Ahn, Kyung-Hyun Min, Won-Soo Yun, Jin-Hyung Shim


P512 Local antibiotic delivery with thermoresponsive hyaluronan hydrogel successfully treats chronic intramedullary nail-related infection in a single stage revision
Willemijn Boot, Matteo D'Este, Fintan Moriarty, Tanja Schmid, Stefan Zeiter, R Geoff Richards, David Eglin

P514 Interpenetrated polymer network hydrogel for guided periodontal regeneration
Pauline Marie Chichiricco, Raphael Riva, Jean-Michel Thomassin, Xavier Struillou, Catherine Le Visage, Pierre Weiss, Christine Jérôme

P515 Interpenetrated polymer network hydrogel for biomedical applications
Pauline Marie Chichiricco, Gildas Rethore, Cecyle Boyer, Jérôme Guicheux, Xavier Struillou, Catherine Le Visage, Pietro Matricardi, Pierre Weiss

P516 Cell proliferation on genipin crosslinked chitosan alginate microcarriers
Chih Yao Chui, Akinlolu Odeleye, Linh Nguyen, Hua Ye

P517 The use of pNIPAM-laponiteÒ hydrogel in 3D-cell culture of the intestine
Rasha Dosh, Nicola Jordan-Mahy, Christopher Sammon, Christine Le Maitre

P518 Injectable hydrogels of cellulose nanofibrils crosslinked with cell culture medium for tissue engineering
Ahmad Rashad, Ellinor Heggset, Kristin Syverud, Kamal Mustafa

P519 Tunable injectable pNIPAM-Laponite® based hydrogels for musculoskeletal regeneration
Abdusalam Essa, Christine LeMaître, Chris Sammon

P520 Self-setting injectable hyaluronic acid hydrogels for tissue engineering applications
Killian Flegeau, Hélène Gautier, Gildas Rethore, Fréderic Tranchepain, Pascal Bordat, Pierre Weiss

P521 Development of human liver extracellular matrix hydrogel for three dimensional cell culture and cell transplantation
Luca Frenguelli, Walid Al-Akkad, Claire Crowley, Manish Tiwari, Alireza Mani, Andrea Telese, Paolo De Coppi, Kevin Moore, Krista Rombouts, Massimo Pinzani, Giuseppe Mazza

P522 Self-assembled peptide gels for intervertebral disc tissue engineering
Simon Wan, Stephen Richardson, Alberto Saiani, Julie Gough

P524 Chitosan coated μicrocarriers fabricated via electrofluidodinamic atomization for oral delivery applications
Vincenzo Guarino, Tania Caputo, Paola Calcanile, Rosaria Altobelli, Christian Dimitri, Luigi Ambrosio

P525 Dense collagen/PLGA composite hydrogels as medicated wound dressings for the treatment of cutaneous chronic wounds: In vitro and in vivo evaluation
Xiaolin Wang, Tuan-Van Nguyen, Olivier Ronsin, Tristan Baumberger, Selim Aractingi, Nicolette Farman, Frédéric Jaisser, Thibaud Coradin, Christophe Helary

P526 Click-crosslinkable collagen hydrogels for skeletal muscle tissue engineering
Roisin Holmes, Giuseppe Tronci, Xuebin Yang, David Wood

P527 Fabrication of injectable hydrogels by modifying carboxymethyl cellulose (CMC) for preventing undesired tissue adhesion
Soohyeon Jeon, Suran Kim, Young-Gwang Ko, Teagyun Yeo, Oh Hyeong Kwon

P528 Modification of alginate to fabricate in situ injectable hydrogel for wound healing
Soohyeon Jeon, Seung Wook Lee, Teagyun Yeo, Oh Hyeong Kwon

P529 Construction of polyethylene glycol-based three-dimensional scaffold customized to the stimulation of human dermal fibroblasts proliferation
Min Seong Kim, Seong Jae Kim, Jung Im Yun, Hye Won Lim, Seung Tae Lee

P530 Application of a modified pullulan hydrogel for injectable anti-adhesion agent
Suran Kim, Young Gwang Ko, Sumi Bang, Jiyoung Lee, Oh Hyeong Kwon

P531 Formation of capillary structures in in vitro trachea model
Franziska Kreimendahl, Sina Ossenbrink, Christian Apel, Stefan Jockenhoevel

P532 Thermally triggered hydrogel delivers mesenchymal stem cells and induces differentiation towards NP phenotype and restores mechanical function following injection into bovine intervertebral disc
Abbey Thorpe, Gary Doughill, Louise Vickers, Glen Cooper, Neil Reeves, Christopher Sammon, Christine Le Maitre

P533 Effective treatment of atopic dermatitis using PVA/Alginate hydrogel containing extract of houttuynia cordata
Tae Ho Kim, Hye Ri Lee, Jin Kyung Park, Se Heang Oh, Jin Ho Lee

P535 Collagen/poly(ethylene glycol) diacrylate cryogels prepared by UV irradiation: tunable macroporous structures for tissue engineering applications
Ugo Masullo, Anna Cavallo, Luca Salvatore, Marta Madaghiele

P537 Mechanical properties of hydrated free-standing films from modified hyaluronan measured by nanoindentation
Jiri Mrazek, Jiri Nohava, Josef Chmelar, Romana Sulakova, Vladimir Velebny

P538 Fabrication of Poly(vinyl alcohol) hydrogel blended with red sea cucumber enhancing cell proliferation of neonatal normal dermal human fibroblast
HyeonHo Park, SooJin Heo, SeokChun Ko, WonKyo Jung

P539 Introduction of strain-stiffening features into elastin-like recombinamers by polyisocyanate hybridization
Leander Poocza, Paula de Almeida, Paul HJ Kouwer, Alan E Rowan, J Carlos Rodríguez-Cabello

P540 trategies to improve the mechanical properties of fibrin scaffolds for tissue engineering of skin
Ana Isabel Ramos-Murillo, Bernardo Camacho Rodríguez, Rubén Darío Godoy-Silva

P545 3D culture of adult stem cells in heparin-HA hydrogel
Kihak Gwon, Eunsol Kim, Giyoong Tae

P548 Hydrazone cross-lined injectable gelatin-hyaluronic acid hydrogels for regenerative medicine
Shujiang Wang, Oommen P Varghese

P549 Discover bio-mimetic hydrogels for stem cell culture
Richard Wetzel, Dejan Husman, Alvin Kuriakose Thomas, Robert Wieduwild, Yixin Zhang

P550 A synthetic HA-Fibrin hybrid proteoglycan for joint preservation and repair
Ezequiel Wexselblatt, Meital BenDayan Bloch, Alon Frank, Avraham Wortzel, Avner Yayon

Biophysical, Biological Cues for Tissue Regeneration

P551 The role of Indian hedgehog and parathyroid hormone related protein in the intervertebral disc
Frances Bach, Willem de Jong, Kim de Rooij, Joyce Zhang, Laura Creemers, Danny Chan, Marianna Tryfonidou

P552 Biological responses of dental pulp stem cells in biomimetic chitosan-gelatin scaffolds in vitro and in vivo
Athina Bakopoulou, Anthie Georgopoulou, Ioannis Grivas, Chrysanthie Bekiari, Katerina Loza, Oleg Prymak, Matthias Epple, George Papadopoulos, Petros Koidis, Maria Chatzinikolaidou

P553 Impact of gap-junctional intercellular communication on adipogenic differentiation of adipose-derived stem cells
Miriam Wiesner, Oliver Berberich, Christiane Hoefner, Torsten Blunk, Bauer-Kreisel Petra

P554 Enhanced delivery of magnetic nanoparticles by GET
Lia Andrea Blokpoel Ferreras, Hareklea Markides, Alicia El Haj, Kevin Shakesheff, James Dixon

P555 Influence of fibre diameter on the tissue reaction of wound dressings - preliminary results of a histological animal study
Friedrich Barsch, Andreas Mamilos, Maximilian Benckendorf, Willi Wagner, Volker Schmitt, Helmut Hierlemann, C James Kirkpatrick, Christoph Brochhausen

P556 A pulmonary heart valve engineered from natural biomaterials
Claire M Brougham, Ricardo Moreira, Tanya J Levingstone, Stefan Jockenhoevel, Petra Mela, Fergal J O'Brien

P557 Expansion at “physiologic” hypoxia attenuates replicative senescence of adipose tissue-derived stromal cells
Ludmila Buravkova Buravkova, Andrey Ratushnyy, Margarita Lobanova, Sergey Buravkov

P558 Understanding matrisomal cues to recreate a pro-regenerative intervertebral disc microenvironment
Joana Caldeira, Cátia Santa, Hugo Osório, Maria Molinos, Bruno Manadas, Raquel Gonçalves, Mário Barbosa

P559 Proof of concept study on preventing post-operative abdominal adhesion
Lucie Bresson, Eric Leblanc, Anne-Sophie Lemaire, Teru Okitsu, Feng Chai

P560 Dealing with healing after incisional bladder wounding
Clara Ibel Chamorro, Xi Liu, Gisela Reinfeldt Engberg, Magdalena Fossum

P561 Low level light therapy stimulates wound healing in a diabetic mouse model in a wavelength dependent manner
Paul Slezak, Claudia Keibl, Sanja Sutalo, Cyrill Slezak, Stefan Rieger, Johannes Hackethal, Heinz Redl, Peter Dungel

P562 Cooperative regulation of hyaluronic acid hydrogel and hypoxia in disc regeneration
Manman Gao, Zhiyu Zhou, Junxuan Ma, Hao Hu, Qihua Qi, Zemin Ling, Liangping Li, Xuenong Zou

P563 Temporal intracellular characterisation of stem cells with external stimulation
Amy Gelmi, Spencer Crowder, Maria Joao Cruz, Alexis Pena, Ali Maziz, Edwin Jager, Molly Stevens

P564 Designing therapeutic delivery scaffolds to recapitulate children’s bone regenerative potential in adults
Arlyng Gonzalez-Vazquez, Sara Barreto, Dylan Murray, Fergal J O'Brien

P565 A continuous pore size gradient PLLA scaffold for osteochondral regeneration
Riccardo Gottardi, Gioacchino Conoscenti, Peter Alexander, Vincenzo La Carrubba, Valerio Brucato, Rocky Tuan

P566 Quality and quantity control cell culture with microgravity for to enhance vasculogenesis of peripheral blood endothelial progenitor cells
Hiroko Hagiwara, Akira Higashibata, Shiho Ogawa, Shigeyuki Kanazawa, Hiroshi Mizuno, Rica Tanaka

P567 Implementation and verification of an efficient, precise, reproducible and accurate automatic quantification method for measuring mesenchymal stromal cell morphological parameters
Melanie Hart, Laura Schmid, Brandan Walters, Bernd Rolauffs

P568 Mimicking the early regenerative response of perivascular stem cells in vitro
Marietta Herrmann, Maria Hildebrand, Mauro Alini, Sophie Verrier

P569 Using bioprinting to investigate the mechanism of axon pathfinding and regeneration
Aljona Kolmogorova, Karin Jansen, Christoph Ballestrem, Brian Derby, Adam Reid

P570 Exogenously-delivered NO Stimulates Elastogenesis by Adult Human Aneurysmal Smooth Muscle Cells
Phillip Simmers, Kurt Farrell, Chandra Kothapalli

P571 Using tissue engineered scaffolds to understand the cellular aspect of bladder regeneration
Hans Mattias Larsson, Elif Vardar, Kalitha Pinnagoda, Jun Ishihara, Ganesh Vythilingam, Eva-Maria Engelhardt, Jeffrey A Hubbell, Peter Frey

P574 Hyperactive mechanism of cardiac fibroblasts against doxorubicin-induced cardiotoxicity
Hayato Magata, Takahiro Iwamiya, Masaru Tomita

P576 Biofunctionalization of chemically-cured urethane pre-polymer coatings for next generation pro-healing cardiovascular implants
Jun Hon Pang, Janice Tsui, Brian Cousins

P577 Overcoming the defect: in vivo bioreactor as solution for generating new resource of autologous bone graft
Ahmad Jabir Rahyussalim

P578 Which endogenous regenerative pathways are activated in human adipose tissue following an injury?
Alessio Romaldini, Fiorella Descalzi, Maddalena Mastrogiacomo, Ranieri Cancedda

P579 Multifactorial approaches for tenogenic phenotype maintenance and function
Christina Ryan, Manus Biggs, Dimitrios Zeugolis

P580 Hyaluronan-based core-shell nanofibres for wound healing and drug delivery
Miroslava Rysová, Lenka Martinová

P581 Pattern induced osteodifferentiation of MSCs: an approach to mimic bone hierarchical structure
Sharanya Sankar, Sindhuja DE, Chandrasekhar Sharma, Subha Narayan Rath

P582 Circulating microRNA analysis upon bone injury
Andreia Silva, José Teixeira, Maria Ines Almeida, Nuno Neves, Daniel Vasconcelos, Cristina Ivan, George Calin, Mário Barbosa, Susana Santos

P583 HIF1A overexpression using protein transduction domain induces angiogenesis in Huvec
Yooseok Shin, Je Seon Song

P584 Biofunctionalisation of electrospun constructs with fibrillin-1 for anterior cruciate ligament repair and regeneration
Zara L Smith, Deepak Kumar, Douglas Ramos Marques, Mingyue Hu, Stuart Cain, Georgia S Critchon, Yalda Ashraf Kharaz, Eithne Comerford, Julie E Gough

P585 Activin A and alkaline phosphatase affect hair inductive potency of human DP cells
Young Sung, Chang Seo, Mi Kwack

P586 Non-contact wettability assessment system for cultivated cells
Nobuyuki Tanaka, Yoshihide Haruzono, Hiromitsu Nasu, Junko Takahara, Akane Awazu, Yo Tanaka

P587 Covalently coated cell stretching devices for osteogenic differentiation of human adipose stem cells
Sanni Virjula, Joni Leivo, Sari Vanhatupa, Kimmo Kartasalo, Joose Kreutzer, Pasi Kallio, Susanna Miettinen

P588 The mechanical stimuli can modulate intracellular calcium oscillation: suggesting pathological model or relevance without chemical cues
Yan Ru Wu, Ji Won Shin, Yun Gyeong Kang, Su Hyang Kim, Mi Jin Kim, Eun Jin Lee, Ji Eun Kim, Jung-Woog Shin

P589 In vitro differentiation of human mesenchymal stem cells into esophageal epithelial cells: a preliminary study for esophageal tissue engineering
Yan Ru Wu, Ji Won Shin, Yun Gyeong Kang, Su Hyang Kim, Mi Jin Kim, Eun Jin Lee, Ji Eun Kim, Jung-Woog Shin

Bone and cartilage engineering by 3D bioprinting and smart biomaterials

P590 Multilayered composite scaffolds induce osteogenesis and chondrogenesis in vitro: possible osteochondral potential
Elisabeth Amann, Amisel Almirall, Martijn van Griensven, Elizabeth Rosado Balmayor

P591 Human bone marrow stem cells direct seeding in three-dimensional printing scaffolds for bone regeneration in a critical-sized calvarial defect model
Ho Yun Chung, Dong Kyu Kim, Dong Hun Choi, Jin Hyung Shim, Won Soo Yoon, Jung Bo Huh, Sung Hwan Moon, Seong Soo Kang

P592 Bi-layered polymer-reinforced bioprinted composites for osteochondral defect regeneration
Gráinne Cunniffe, Eamon Sheehy, Susan Critchley, Pedro Díaz-Payno, Simon Carroll, Pieter Brama, Daniel Kelly

P593 Additive manufacturing of 3D nanocomposite magnetic scaffolds
Ugo D'Amora, Teresa Russo, Alfredo Ronca, Antonio Gloria, Roberto De Santis, Luigi Ambrosio

P594 Design of additive manufactured structures with functional gradients for interface tissue engineering
Ugo D'Amora, Matteo D'Este, David Eglin, Antonio Gloria, Roberto De Santis, Mauro Alini, Luigi Ambrosio

P595 Protein surface modifications for cell membrane attachment in tissue engineering and regenerative medicine
Robert Deller, James Armstrong, Adam Perriman

P596 Two-cell bioprinting for bone tissue engineering application
Sindhuja Devi Eswaramoorthy, Akshat Joshi, Akshay Joshi, Subha Narayan Rath, Suryakumar S

P598 Steps forward to bioprinting of vascularized bone tissue equivalents
Annika Wenz, Iva Tjoeng, Julia Rogal, Nicolai Wilk, Kirsten Borchers, Petra J Kluger

P599 In vivo analysis of the 3D-scaffold biodegradation according to the level of autofluorescence
Daria Kuznetsova, Peter Timashev, Anastasia Koroleva, Boris Chichkov, Victor Bagratashvili, Elena Zagaynova

P601 On demand fabrication of bone grafts by direct ink writing: from tomography to patient specific implants
Edgar B Montufar, Mariano Casas-Luna, Jorge A Torres-Rodríguez, Adam Brinek, Dominika Kalasova, Tomáš Zikmund, Lucy Vojtová, Ladislav Celko, Jozef Kaiser

P602 Development of flexible hybrid films for tissue engineering
Dipankar Das, Sumi Bang, Insup Noh

P603 Adhesive, remineralising and antibacterial composites for vertebral fracture repair
Caitriona O'Rourke, Piyaphong Panpisut, Anne M Young

P604 Evaluation of injectable gellan-gum hydrogel for articular tissue cartilage regeneration
Hyun Park, Jeong Eun Song

P605 Surface influence of bioactive calcium phosphate- or calcium carbonate-containing silica/collagen xerogels on osteoblasts, osteoclasts and macrophages
Sina Rössler, Benjamin Kruppke, Francisca Alagboso, Seemun Ray, Volker Alt, Thomas Hanke

P606 A novel micro-computed tomography procedure for the quality control of personalized 3D-printed implants: an illustration using stereolithography-printed scaffolds
Vincent A Stadelmann, Mike Geven, Dirk Grijpma, R Geoff Richards, David Eglin, Olivier Guillaume

P607 Titanium reinforced PLGA / collagen multi-layered osteochondral scaffold for repair of large osteochondral defects
Maryam Tamaddon, Gordon Blunn, Andy Goldberg, Chaozong Liu

P608 The influence of mechanical properties of 3D bioprinted hMSCs-laden alginate composite scaffolds on cell viability and morphology
Jianhua Zhang, Marina Rubert, Jolanda Baumgartner, Esther Wehrle, Graeme Paul, Ralph Müller

Cartilage tissue engineering

P609 Evaluation of human hyaline and elastic chondrocyte differentiation in nanostructured fibrin-agarose hydrogels
Laura A Garcia-Martinez, Fernando Campos, Daniel Durand-Herrera, Boris D Jaimes-Parra, Miguel-Angel Martin-Piedra, Ingrid Garzon, Juan Garrido-Gomez, Gloria Carmona, Victor Carriel

P610 Effects of FGF18 on OA human articular chondrocytes embedded in a novel FBG:HA hydrogel
Bernardo Antunes, João Pedro Garcia, Efrat Monsonego-Ornan, Laura Creemers, Avner Yayon

P613 Osteochondral tissue regeneration with biofunctional hydrogel scaffolds based on MSCs embedded in an Elastin-Like Recombinamers matrix
Filippo Cipriani, Israel González de Torre, Aurelio Vega Castrillo, Blanca Ariño Palao, Angel Àlvarez Barcia, José Carlos Rodríguez-Cabello

P614 Injured articular cartilage releases both migratory/homing factors and a purinergic priming factor which are mandatory for homing of mesenchymal stem cells to cartilage lesions
Saima Ahmed, Dave Buttle, Sarrawat Rehman, Edward Draper, Aileen Crawford

P615 Biomimetic, biofunctionalised, polymer implants to promote in situ repair of traumatic and early osteoarthritic cartilage defects
Dave Buttle, John Haycock, Richard Meeson, Matthew Pead, Gordon Blunn, Aileen Crawford

P616 Nano-ghosts delivery system and Link-N peptide, enhanced anti-inflammatory activity: a new approaches for the treatment of osteoarthritis
Domenico D'Atri, Marcelle Machluf

P617 Histological evaluation of fibrochondrocyte and articular chondrocyte micro-aggregates for modular tissue engineering of fibrocartilage
Lise De Moor, Elien Beyls, Heidi Declercq, Ria Cornelissen

P618 Influence of an anabolic loading period on global chondrocyte gene expression in osteochondral tissue engineering constructs
Elisabeth Krämer, Simone Scholtes, Melanie Weisser, Wolfgang Roth, Reto Luginbühl, Tobias Grossner, Jennifer Fischer, Wiltrud Richter

P619 Electrospinning of functionalized poly(ε-caprolactone) for sustained drug delivery
Florian Formica, Giulia Morgese, Marcy Zenobi-Wong

P620 Combined effect of hypoxia and matrix elasticity during chondrogenic differentiation of human mesenchymal stem cells
Daniel Foyt, Dheraj Taheem, Marcus Dawson, Holger Auner, Gavin Jell, Eileen Gentleman

P621 Advancing osteochondral tissue regeneration by ordered differentiation of human periosteal cells
Luís Filipe Mendes, Hiroki Katagiri, Wai Long Tam, Yoke Chin Chai, Liesbet Geris, Scott Roberts, Frank Luyten

P624 Nasal chondrocytes are potential autologous cell-transplant candidates for treating degenerative disc disease
Max H-P Gay, Arne Mehrkens, Andrea Barbero, Ivan Martin, Stefan Schären

P625 Platelet derivatives stimulate cartilage repair activating progenitor cells and maintaining human hyaline cartilage phenotype by Chondromodulin-I induction
Daniela Martinelli, Rui Cruz Pereira, Ranieri Cancedda, Chiara Gentili

P626 Preclinical study of a novel cell-free biphasic scaffold for osteochondral lesions in a sheep model
Francesca Gervaso, Laura Mangiavini, Alessia Di Giancamillo, Federica Boschetti, Daniela Izzo, Davide D Zani, Mauro Di Giancamillo, Irene Tessaro, Marco Domenicucci, Francesca Scalera, Cinzia Domenighini, Antonio Crovace, Alessandro Sannino, Giuseppe M Peretti

P627 A cartilage lesion in a soccer players knee - treated with MACI followed by histological evaluation
David Grevenstein, Leonard Westermann, Matthias Hansen, Charles James Kirkpatrick, Christoph Brochhausen

P628 Influence of genipin-based crosslinking treatments on collagen scaffold properties for cartilage regeneration
Fabiana Gullotta, Daniela Izzo, Francesco Legge, Paola Occhetta, Ivan Martin, Alessandro Sannino, Francesca Gervaso

P629 Cartilage regeneration on saponin loaded gellan gum scaffolds
Ha Yan Jeon, Il Nam Choi, Yoo Sshin Jeon, Jong Ho Park, Eun Yeong Shin, Joo Hee Choi, Jeong Eun Song, Nirmalya Tripathy, Gilson Khang

P630 Enhancement of chondrogenic differentiation using gellan gum hesperidin hybrid scaffold
Sung Hyun Jeon, WonTaek Lee, Hyun Park, Il Nam Choi, Jeong Eun Song, Chan Hum Lee, Dong Won Suh, Joohee Choi, Gilson Khang

P631 Differential effects of platelet-derived products on ECM turnover by OA chondrocytes in collagen hydrogels
Vivek Jeyakumar, Eugenia Niculescu-Morzsa, Christoph Bauer, Daniela Kern, Zsombor Lacza, Stefan Nerer

P633 Successful cartilage regeneration by stem cells and cartilage fragments covered by amniotic membrane in an equine osteochondral defect model
Julia Lerchbacher-Hieslmayr, Elizabeth R Balmayor, Elisabeth Amann, Peter Foehr, Dirk Barnewitz, Martijn van Griensven

P634 Spatial organization of chondrocytes influences cartilage repair in an ex vivo osteochondral plug model
Vivian Mouser, Riccardo Levato, Noel Dautzenberg, Mattie van Rijen, Wouter Dhert, Debby Gawlitta, Jos Malda

P635 Optimization of an injectable, growth-factor loaded hyaluronan hydrogel for cartilage repair
Clara Levinson, Nicolas Broguiere, Marcy Zenobi-Wong

P637 Strategies to enhance chondrogenic differentiation of dental pulp stem cells
Alessia Longoni, Inge EM Hooijdonk, Gerhard KP Bittermann, AJWP Rosenberg, Debby Gawlitta

P639 Use of alginate-agarose scaffolds for cartilage regeneration
María Oliver, Manuel Mata, Lara Milian, María Sancho-Tello, Martín de Llano José Javier, Carmen Carda

P640 Human dental pulp stem cells cultured in alginate hydrogels for cartilage regeneration 
Manuel Mata, José Javier Martín de Llano, Javier Zurriaga, Lara Milián, María Sancho-Tello, Carmen Carda

P641 Role of Matrilin-3 in chondrogenesis of mesenchymal stem cells
Manjunatha Muttigi, Byoung Ju Kim, Inbo Han, Hansoo Park, Soo-Hong Lee

P642 The importance of after seeding treatment during re-swelling time of the scaffold after compression release-induced suction seeding technique
Naser Nasrollahzadeh, Dominique P Pioletti

P643 How to get cells in a dense cartilage matrix?
Sylvia Nürnberger, Cornelia Schneider, Bernhard Rieder, Andreas Teuschl, Johannes Zehetner, Gerjo van Osch, Heinz Redl, Susanne Wolbank

P644 Progenitor cells in auricular cartilage demonstrate promising cartilage regenerative potential in 3D hydrogel culture
Iris A Otto, Riccardo Levato, Richard W Webb, Ilyas M Khan, Corstiaan C Breugem, Jos Malda

P645 Platelet activated scaffolds guide cartilage rib regeneration during tissue development
Maria Elisabetta Federica Palamà, Daniela Martinelli, Michele Torre, Ranieri Cancedda, Chiara Gentili

P646 Development of an in vitro model mimicking early osteoarthritis using mesenchymal stem cells undergoing chondrogenic differentiation
Girish Pattappa, Jennifer Seja, Isabelle Hofmeister, Johannes Zellner, Denitsa Docheva, Peter Angele

P647 Articular cartilage regeneration in osteoarthritis rat model
Karthikeyan Rajagopal, Sanjay K Chilbule, Noel Walter, Vivek Dutt, Vrisha Madhuri

P648 Chitosan-gelatin nanocomposite scaffold for articular cartilage regeneration
Karthikeyan Rajagopal, Poonam Sharma, Sowmya Ramesh, Vivek Dutt, Balakumar B, Abhay D Gahukamble, Noel M Walter, Dhirendra S Katti, Vrisha Madhuri

P651 Graphene oxide is an effective growth factor delivery vehicle inducing human MSC chondrogenesis
Mi Zhou, Stephen Richardson, Kostas Kostarelos, Judith Hoyland

P652 Results of a composite chitosan-based scaffold for the osteochondral tissue regeneration in animal models
Alice Roffi, Francesco Perdisa, Simone Sprio, Monica Sandri, Anna Tampieri, Maria Sartori, Francesca Salamanna, Annapaola Parrilli, Milena Fini, Elizaveta Kon, Maurilio Marcacci, Giuseppe Filardo

P653 Cartilage differentiation of hBM-MSCs on human wharton's jelly-derived scaffolds
Fatemeh Safari, David Eglin, Mauro Alini, Martin J Stoddart, Mohammadreza Baghaban Eslaminejad

P655 The role of autophagy during chondrodifferentiation of human mesenchymal stem cells
Souzan Salemi, Christopher Millan, Tullio Sulser, Marcy Zenobi, Daniel Eberli

P656 Biomechanical and histological evaluation of spontaneous cartilage regeneration in two different defect models in rabbits
Hagen Schmal, Anke Bernstein, Katharina Böttiger, Eva Johanna Kubosch

P657 Artificial tissue cutter: creation of standardized chondral defects in an osteochondral model
Andrea Schwab, Sebatian Naczenski, Alexa Buss, Heike Walles, Franziska Ehlicke

P658 Mechanical and image analysis of porous PGSm particles cultured in vitro as scaffolds for cartilage repair
Dharaminder Singh, Aileen Crawford, Frederik Claeyssens

P660 Fabrication of tendon and cartilage tissue constructs with commercially available polymers
Kyriakos Spanoudes, Elif Nur Yilmaz, Yves Bayon, Dimitrios Zeugolis

P661 Chondrogenic induction of mesenchymal stem cells by the combination of kartogenin and 3D tri-copolymer scaffolds in a self-designed bioreactor system
Yu-Jun Sun, Chunching Li, Ching-Yun Chen, Jui-Sheng Sun, Feng-Huei Lin

P662 An automated bioreactor to determine the effects of post-operative rehabilitation protocols on articular chondrocytes
Giuseppe Talo, Silvia Lopa, Stefano Rottigni, Matteo Moretti

P663 Micro/Nano-technology for physeal growth plate engineering
Li Min Tay, Christian Wiraja, Chenjie Xu, Yingnan Wu, Zheng Yang, Eng Hin Lee, Claus-Dieter Ohl

P664 Influence of matrix properties of cartilage bioimplants on human chondrogenic progenitor cells
Katharina Tluczynski, Katja Hasch, Hanna Tritschler, Ludwig Koerber, Helga Joos, Jörg Fiedler, Rolf Brenner, Rainer Buchholz, Roman Breiter, Nicole Rotter

P665 Generation of three-dimensional (3D) engineered articular cartilage using Human ESCs
Paweena Uppanan, Christopher Leon Valdivieso, Roberto Donno, Nicola Tirelli, Marco Domingos, Christoph Ballestrem, Susan Kimber

P666 Biomimetically surface modified fibres for cartilage regeneration
Olga Urbanek, Pawel Sajkiewicz

P667 Novel ex-vivo osteochondral defect model in a joint bioreactor system for articular cartilage repair studies
M Letizia Vainieri, Dieter Wahl, Patrick Leuzo, Gerjo van Osch, Mauro Alini, Sibylle Grad

P668 rAAV-mediated sox9 overexpression induces chondrogenesis in human bone marrow aspirates seeded in woven poly(ε-caprolactone) scaffolds
Jagadeesh Kumar Venkatesan, Frank Moutos, Ana Rey-Rico, Janina Frisch, Gertrud Schmitt, Farshid Guilak, Henning Madry, Magali Cucchiarini

P669 Organized tetra-copolymer scaffold regulated the human synovium-derived stem cells for cartilage tissue engineering: an in vitro study
Chen-Chie Wang, Pei-Yu Chen, Chang-Chin Wu, Kai-Chiang Yang

P671 Macro-porous micro-carriers as a vehicle for chondroprogenitor expansion and scaffold formation for the rapid biofabrication of osteochondral implants
William Webb, Riccardo Levato, Navid Moshkbouymatin, Yadan Zhang, Lewis Francis, Rene van Weeren, Jos Malda, Ilyas Khan

Endogenous stem cells mobilization for tissue regeneration

P672 Collagen gel as a scaffold for mesenchymal stem cells and chitosan nanoparticles for a tissue-engineered brain patch to promote neural regeneration
Sarah Anderson, Marisa Kager, Ronak Bhatia, Ramita Kondepudi, Elizabeth Orwin

P673 Fishing nucleus pulposus progenitor cells from bovine intervertebral discs using three different sorting methods
Daniela Frauchiger, Adel Tekari, Lorin M Benneker, Daisuke Sakai, Sibylle Grad, Jivko Stoyanov, Alessandro Bertolo, Benjamin Gantenbein

P674 The role of surface topography on cellular dynamics of peri-implant angiogenesis and osteogenesis
Niloufar Khosravi, Azusa Maeda, Vanessa Mendes, Michael T Underhill, Ralph S DaCosta, John E Davies

P675 Covalent immobilization of stromal cell derived factor 1α-derived peptide and heparin on poly(L-lactide-co-ε-caprolactone) copolymers for in situ tissue regeneration applications
Muhammad Shafiq, Soo Hyun Kim

Enhancement of endogenous tissue repair

P676 Injectable photocrosslinkable hyaluronic acid hydrogels incorporated with platelet lysate for dental pulp endogenous regenerative therapy
Pedro Babo, Leopoldina Almeida, Josimeri Hebling, Rui Reis, Manuela Gomes

P677 First characterization of human amniotic fluid stem cell extracellular vescicles as a powerful paracrine tool endowed with regenerative potential
Carolina Balbi, Martina Piccoli, Lucio Barile, Andrea Papait, Andrea Armirotti, Elisa Principi, Daniele Reverberi, Luisa Pascucci, Pamela Becherini, Luigi Varesio, Massimo Mogni, Domenico Coviello, Tiziano Bandiera, Michela Pozzobon, Ranieri Cancedda, Sveva Bollini

P678 The human amniotic fluid stem cell secretome as a new paracrine source to unlock endogenous cardiac regeneration
Carolina Balbi, Lucio Barile, Silvia Moimas, Andrea Armirotti, Francesco Santini, Tiziano Bandiera, Domenico Coviello, Ranieri Cancedda, Mauro Giacca, Sveva Bollini

P679 The inflammatory phenotype of infrapatellar fat pad can be modulated by triamcinolone acetonide, probably via the residing macrophages
Serdar Capar, Wu Wei, Jan AN Verhaar, Stefan Clockaerts, Gerjo JVM van Osch, Yvonne M Bastiaansen-Jenniskens

P680 The potential of porcine peritoneum tissue as an anti-adhesion barrier for flexor tendon regeneration
Héctor Capella-Monsonís, Dimitrios I Zeugolis

P681 Photosynthetic sutures with pro-regenerative features
Carolina Centeno-Cerdas, Montserrat Jarquín-Cordero, Myra Noemi Chávez, Ursula Hopfner, Daniel Schmauss, Jörg Nickelsen, Hans-Günther Machens, José-Tomás Egaña

P682 Molecular and histological analysis of the corpus spongiosum
Petra de Graaf, Rana Ramadan, Nico Staller, Natasja Carpitella, Krista den Ouden, Antoni Hendrickx, Gary Pigot, Erik Meuleman, Mark Bram Bouman, Mudje Özer, Ruud Bosch, Laetitia de Kort

P683 Alginate and hyaluronic acid as injectable hydrogels to apply BMP2-loaded microspheres induced differences in macrophage infiltration, vascularisation and bone formation
Shorouk Fahmy-Garcia, Didem Mumcuoglu, Laura de Miguel, Veerle Dieleman, Bram van der Eerden, David Eglin, Sebastiaan Kluijtmans, Gerjo van Osch, Eric Farrell

P684 Platelet-rich plasma treated tibial side 3rd grade rupture of medial collateral ligament
Jussi Kosola, Hero Mali, Jacob Hyde, Jarkko Levola

P685 Attachment studies of peri-implantitis-associated pathogens to titanium and cobalt chromium and the development of an antimicrobial coating
Clotilde Haury, Andrew Wescott, David Beeby, Bryan Austin, Simon Jones, Wayne Ayre, Rachel Waddington, Alastair Sloan

P686 Fabrication, characterization and determination of biological activities of poly (ε-caprolactone)/chitosan-caffeic acid composite fibrous mat for wound dressing
Seong-Yeong Heo, Gun-Woo Oh, Seok-Chun Ko, Jae-Young Je, Young-Mok Kim, Won-Kyo Jung

P687 Adult astrocyte scratch wound model: evaluation of treatment for traumatic brain injury
Ramita Kondepudi, Andrew Marino, Elizabeth Orwin

P688 Anti-adipogenic factors in platelet rich plasma counter its pro-adipogenic effects, while serum from platelet rich fibrin supports stem cells adipogenic differentiation
Olga Kuten, Melinda Simon, Stefan Nehrer, Zsombor Lacza

P690 Building a tool box to assess the risk of undesired proliferation associated with regenerative medicine approaches during early drug discovery
Maria Liljevald, Julia Johansson, Patrik Andersson, Mikael Persson, Jorrit Hornberg

P692 Dynamic biomaterials that direct cell migration via a chemoattractant gradient to enhance meniscal repair
Feini Qu, Julianne Holloway, Jason Burdick, Robert Mauck

P693 Human platelet-derivatives for clinical-grade expansion of mesenchymal stem cells from different tissue sources
Siddharth Shanbhag, Samih Mohamed, Turid Helen F Lunde, Petra Vogelsang, Tor Hervig, Kamal Mustafa

P695 Preliminary tests of murine myoblasts culture for the treatment of muscle injuries caused by bothrops asper venom
Andrea Ulloa Fernández, Silvia Castro Piedra, Miguel Rojas Chaves, Alexandra Rucavado Romero

P696 Role of CD146 in mesenchymal stem cell homing and regeneration of the intervertebral disc: an in vitro and whole organ culture study
Sebastian Wangler, Ursula Menzel, Zhen Li, Lorin M Benneker, R Geoff Richards, Mauro Alini, Marianna Peroglio, Sibylle Grad

Gene therapy - new messages towards regeneration

P698 Prepration of connective tissue growth factor siRNA /Low density lipoprotein nanocomplex and attenuation of scar formation by modulating ultra-structural collagen organization
Yunjo Choi, Heekyung Moon, Jaegwan Lee, Ae-Ri Cho Lee

P699 Optimizing electroporation parameters for non-viral transfection of primary intervertebral disc cells for tissue engineering 
Rahel May, Adel Tekari, Daniela Frauchiger, Anna Krismer, Lorin Benneker, Benjamin Gantenbein

P700 Human muscle precursor cells overexpressing PGC-1α support early myofiber formation for bioengineering of slow twitch sphincter muscle
Deana Mohr-Haralampieva, Souzan Salemi, Daniel Eberli

P701 Nanoghosts targeted delivery of RNA interference therapy for the treatment of Osteoarthritis
Jacopo Oieni, Marcelle Machluf


P702 Pre-conditioning of dental pulp-derived cell spheroids with hypoxia and hypoxia mimetic agents
Klara Janjić, Michael Edelmayer, Umar Alhujazy, Bledar Lilaj, Andreas Moritz, Hermann Agis

P703 Evaluation of cell isolation methods for the generation of oral mucosa keratinocytes as an advanced therapies medical products
Ingrid Garzon, Fernando Campos, Daniel Durand-Herrera, Boris D Jaimes-Parra, Miguel-Angel Martin-Piedra, Ignacio Guerrero, Ricardo Fernandez-Valades, Victor Carriel, Maria del Carmen Sanchez-Quevedo

P704 Clinical translation of a fibrin-agarose skin substitute generated by tissue engineering
Victor Carriel, Ingrid Garzon, Boris D Jaimes-Parra, Alajandro Vela-Romera, Miguel Alaminos, Antonio M Lizana-Moreno, Antonio Ruiz-Garcia, Salvador Arias-Santiago, Antonio Campos, Ricardo Fernandez-Valades

P705 Local depth-dependent nanoindentation measurements of human articular cartilage
Jens Antons, Matteo Marascio Gregorio Modesto, Jiri Nohava, Pierre-Etienne Bourban, Dominique P Pioletti

P706 Co-culture of endothelial and myogenic stem cells: strategies and applications for tissue engineering
Daiva Baltriukiene, Evaldas Balciunas, Tatjana Kochane, Saulute Budriene, Ingrida Bruzaite, Evaldas Liutkevicius, Virginija Bukelskiene, Romualda Vaineikyte, Daiva Jasmontaite

P707 Oxidative status predicts quality in human mesenchymal stem cells
Alessandro Bertolo, Simona Capossela, Gion Fränkl, Martin Baur, Tobias Pötzel, Jivko Stoyanov

P708 Tumor targeting therapy and magnetic hyperthermia on breast cancer cells by doxorubicin-bioconjugated carboxylic acid magnetic nanoparticles
Enrico Catalano, Jürgen Geisler, Vessela N Kristensen

P711 Effect of TGF-β1 on the plasminogen activation system, TIMP-1 and N-cadherin expression of stem cells from the apical papilla (SCAP) and the related signalling pathways
Mei-Chi Chang, Jiiang-Huei Jeng, Hsiao-Hua Chang, Ju-Hsiu Cheng

P712 The effect of adipose tissue derived mesenchymal stem cells for the regeneration of radioiodine-induced salivary gland dysfunction
Jeong-Seok Choi, Jeong Mi Kim, Young-Mo Kim

P713 Specific moieties carrying nanotracers for gene therapy and tracking the human mesenchymal stem cells
Ji Sun Park, Ok-Hee Lee, Shangho Lee, Sohyeon Moon, Keun-Hong Park, Youngsok Choi

P714 A combined theoretical and experimental strategy to inform the choice of cell density in engineered tissue constructs to maximise therapeutic cell survival
Rachel Coy, Georgina Kennedy, Paul Kingham, James Phillips, Rebecca Shipley

P715 Cellular studies of electrospun PCL/biocomponent nanofibers from alternative and traditional solvents
Judyta Dulnik, Dorota Kolbuk, Piotr Denis, Pawel Sajkiewicz

P716 Effect of exosomes from human induced pluripotent stem cells on skin wound healing in diabetic mice
Katsumi Ebisawa, Hitoshi Kobayashi, Aika Yamawaki-Ogata, Hidetaka Suga, Keisuke Takanari, Yuzuru Kamei

P718 Evaluation of commercially available cryopreservation media for the cryopreservation of MSCs expanded in a novel xeno-free medium
Seán Gaynard, Georgina Shaw, Fiona Curley, Frank Barry, Mary Murphy

P719 The effect of fibronectin during the isolation and expansion of bone marrow derived mscs isolated in a novel xeno-free medium
Georgina Shaw, Seán Gaynard, Niamh Duffy, Frank Barry, Mary Murphy

P720 The effect of changing oxygen tension during culture and differentiation of bone marrow derived mesenchymal stem cells isolated and expanded in a novel xeno-free medium
Seán Gaynard, Georgina Shaw, Frank Barry, Mary Murphy

P721 Development of cell manufacturing incubator integrating isorator technology for maintaining aseptic environment for an extended period of time
Katsuki Hashimoto, Kazuhito Tanimoto, Kazuhiro Fukumori, Manabu Mizutani, Masahiro Kino-Oka

P722 Engineering of axially vascularized bone grafts towards the treatment of avascular bone necrosis
Alexander Haumer, Tarek Ismail, Rik Osinga, Laurent Tchang, Atanas Todorov, Nima Allafi, Rene Largo, Alexandre Kaempfen, Ivan Martin, Dirk Johannes Schaefer, Arnaud Scherberich

P723 Collagen-chitosan membranes crosslinked with EDC for guided bone regeneration
José Luis Hidalgo Vicelis, Susana Patricia Miranda Castro, María Cristina Piña Barba

P724 The control of stem cell differentiation using peptide-targeted delivery of biodegradable nanoaprticles
Aveen Jalal, James Dixon, Kevin Shakesheff

P725 Effect of TGF-ß1 on the expression of N-cadherin, plasminogen-activated inhibitor-1, TIMP-1 proteins in stem cells from human exfoliated deciduous teeth (SHED): Role of ALK5/Smad2/3, TAK1 and MEK/ERK signal transduction pathways
Jiiang-Huei Jeng, Mei-Chi Chang, Ju-Hsiu Cheng, Hsiao-Hua Chang, Chiu-Po Chan

P726 Influence of processing parameters for 3D bioprinting
Benjamin Kessel, Marcy Zenobi-Wong

P727 In vitro and in vivo application of scaffold-free tissue reconstructed by endometrial stromal cells
Jeonghyun Kim, Takayuki Harada, Yasushi Hirota, Takehiro Hiraoka, Osamu Yoshino, Shigeru Saito, Yutaka Osuga, Takashi Ushida, Katsuko Furukawa

P728 Piezoelectric dermal patch for wound healing
Byung-Soo Kim, Woo Soon Jang, Hong Koo Baik, Eungkyu Lee, Youn Sang Kim, Suk Ho Bhang, Jin Han, Jeong-Kee Yoon, Wan-Geun La, Tae-Jin Lee, Jung-Youn Shin, Sung Pil Kwon

P729 Modulation of the secretory potential of in vitro adipose tissue microenvironments
Manuela EL Lago, Mariana T Cerqueira, Rogério P Pirraco, Marina Costa, Rui L Reis, Alexandra P Marques

P730 Fabrication and characterization of fluorescent silk particle for tissue engineering
Ok Joo Lee, Chan Hum Park, Hae Sang Park

P731 Development of a novel 3D organotypic human HepaRG-based non-invasive optical imaging platform for pre-clinical hepatotoxicity screening
Nicole Martucci, Katie Morgan, Graham Anderson, Leonard Nelson, Pierre Bagnaninchi

P732 Two-photon FLIM in the study of mesenchymal stem cells metabolic plasticity
Aleksandra Meleshina, Varvara Dudenkova, Alena Bystrova, Marina Shirmanova, Elena Zagaynova

P733 The role of collagenase in the isolation of adipose tissue-derived mesenchymal stem cells - aspects of risk assessment
Juliane Meyer, Günter Kamp, Kirsten Peters

P734 Bone non union treatment by autologus cells grafts
Viorel Nacu, Gheorghe Croitoru, Stanislav Cosciug, Vitalie Cobzac, Stella Samson

P735 AUTOSTEM: a closed robotic platform for the automated expansion of mesenchymal stem cells
Jelena Ochs, Michael Kulik, Robert Schmitt

P736 Characterization of basic mechanical properties among wet and dry unaligned electrospun collagen matrices and rabbit corneas
Cesar Orellana, Elizabeth Orwin

P737 Modified cell penetrating peptides for efficient gene delivery in vivo
Gizem Osman, Hosam Abu Awwad, Kevin Shakesheff, James Dixon

P739 Clinically-relevant solution for hypothermic storage and transportation of human multipotent mesenchymal stromal cells
Yuriy Petrenko, Tomáš Groh, Eliška Kosnarová, Irena Vacková, Zuzana Kocí, Alexander Petrenko, Eva Syková, Šárka Kubinová

P740 Characterization of in vitro expanded human Adipose-derived stem cells: implication in regenerative medicine
Adriana Schumacher, Maciej Zieliński, Paulina Langa, Anna Wardowska, Milena Deptuła, Karolina Kondej, Jacek Zieliński, Mirosława Cichorek, Piotr Trzonkowski, Michał Pikuła

P741 Hypothermic preservation of confluent human adipose stem cells
Sara Ribeiro, Andreia Carvalho, Marina Costa, Mariana Cerqueira, Alexandra Marques, Rui Reis, Rogério Pirraco

P742 An ageing disease model from Progeria induced pluripotent stem cells identify an anti-ageing compound
Patricia R Pitrez, Helena Vazão, Luís Estronca, Anne-Laure Egesipe, Claire Navarro, Annachiara De Sandre-Giovannoli, Xavier Nissan, Lino Ferreira

P743 Analysis of fiber diameter of electrospun collagen, gelatin, and PLLA/laminin nanofibers for the production of a bioengineered cornea
Elizabeth Poss, Briana Liu, Elizabeth Orwin

P744 Accelerating critical-sized bone defect repair using gene therapy: design of highly efficient gene-activated scaffolds for bone tissue regeneration
Rosanne Raftery, Irene Mencia Castano, Caroline Curtin, Gang Chen, Brenton Cavanagh, Sally-Ann Cryan, Fergal O'Brien

P745 Smooth muscle tissue expansion for purposes within regenerative medicine
Gisela Reinfeldt Engberg, Clara Ibel Chamorro, Agneta Nordenskjöld, Magdalena Fossum

P747 Laser microtomy for histology and histochemistry of implants and hard tissue
Heiko Richter, Serge Rousselle, Armando Tellez, Brian Tabb, Isabel Bleeker, Anja Osterberg, Brigitte Müller-Hilke, Birgitta Stolze

P748 Cell manufacturing with an aseptic transfer interface to be standardized
Kazuhito Tanimoto, Mamoru Kokubo, Manabu Mizutani, Motohiro Hirose, Masahiro Kino-Oka

P749 Biodegradable elastomeric scaffolds of poly(glycerol sebacate): key synthesis issues
Álvaro Conejero-García, Héctor Rivero-Gimeno, Yolanda Moreno-Sáez, Isabel Ortuño-Lizarán, Alba Muñoz-Santa, Peter Walsh, Guillermo Vilariño-Feltrer, Ana Vallés-Lluch

P750 PLA/PCL electrospun membranes of different fibres diameter as culture supports and delivery of albumin thereof
María Herrero-Herrero, José Antonio Gómez-Tejedor, Ana Vallés-Lluch

P751 MicroRNA-mediated chondrogenic differentiation of mesenchymal stem cells
Lucienne Vonk, Robin Coopmans, Leander Vonk, Daniel Saris, Hugo Fernandes

Hydrogels in tissue engineering: Progress and challenges

P759 Characterisation of monocyte-laden hydrogel based on hyaluronic acid and gelatin
Julie Bystronova, Ivana Scigalkova, Martin Pravda, Nihal Engin Vrana, Toomas Neuman, Urmas Liivas, Vladimir Velebny

P760 Extracellular matrix hydrogel derived from decellularised intestinal tissue for the 3D-culture of intestinal stem cells for tissue engineering applications
Claire Crowley, Martina De Santis, Luca Urbani, Alfonso Tedeschi, Laween Meran, Sang-Eun Lee, Sara Campinoti, Vivian Li, Paola Bonfanti, Alan Burns, Simon Eaton, Martin Birchall, Paolo De Coppi

P761 A UV crosslinked IPN hydrogel loaded with ADSC to promote vascularization for tissue engineered skin
Gozde Eke, Naside Mangir, Nesrin Hasirci, Sheila MacNeil, Vasif Hasirci

P763 Hydrogel complex containing bioactive molecules for regenerative repair of locally ionizing radiation damaged tissue
Sang Joon Park, Wheemoon Cho, Yong-Hee Kim, Chun-Ho Kim

P764 Evaluating the effect of matrix stiffness on corneal fibroblast phenotype in the development of a tissue-engineered cornea
Michelle Lanterman, Neil Forsythe, Liz Orwin

P765 Bioadhesive gelatin hydrogel formed by dual enzymatic cross-linking to assist in situ tissue regeneration
Thi Phuong Le, Yunki Lee, Dai Hai Nguyen, Ki Dong Park

P766 Lysyl-oxidase-like 2 (LOXL2)- mediated biomimetic cross-linking of collagen and elastin hydrogels for improved vascularisation of tissue constructs
Laurent Bidault, Andrea Heinz, Christophe Helary, Catherine Monnot, Christian Schmelzer, Thibaud Coradin, Stéphane Germain,Laurent Muller

P767 ECM from decellularised tissues as an additive for polysaccharidic hybrid gels
Elena Marcello, Alessandro F Pellegata, Claudia Tresoldi, Daniela P Pacheco, Sara Mantero, Paola Petrini

P768 Hydrogel impregnation of bone chips allows prolonged cefazolin release
Guy Putzeys, Christiane Duportail, Kathleen Croes, Michaël Boudewijns, Lieven Thorrez

P769 Development of photo-crosslinkable gelatin and κ-carrageenan for adipose tissue engineering
Liesbeth Tytgat, Hugo Thienpont, Heidi Ottevaere, Peter Dubruel, Sandra Van Vlierberghe

Immunomodulation and Immune Engineering in Regenerative Medicine

P770 ECM-mimicking biomembrane as a directional delivery system to control biological events in cell laden hydrogel
Julien Barthès, Helena Knopf-Marques, Lucie Wolfova, Géraldine Koenig, Jalal Bacharouche, Grégory Francius, Helle Sadam, Urmas Liivas, Philippe Lavalle, Engin Nihal Vrana

P771 Establishing the crosstalk between macrophages and fibroblasts or endothelial cells in 3D hydrogel microenvironment for tissue engineering applications
Julien Barthès, Camille Dollinger, Céline Muller, Helena Knopf-Marques, Helle Sadam, Urmas Liivas, Philippe Lavalle, Nihal Engin Vrana

P773 Influence of surface modified poly(L-lactic acid) films on the differentiation of human monocytes into macrophages
Clara Correia, Joana Gaifem, Mariana Oliveira, Ricardo Silvestre, João Mano

P774 Dissecting mesenchymal stem/stromal cells secretome to modulate the inflammatory response of degenerated intervertebral disc
Joana Rita Ferreira, Graciosa Teixeira, Mário Barbosa, Raquel Gonçalves

P775 Titanium induces expression of metallothioneins in primary human monocyte-derived macrophages and enhances their intracellular bacterial killing capacity
Julia Michel, Alexandru Gudima, Vladimir Ryabov, Nihal Engin Vrana, Harald Klüter, Julia Kzhyshkowska

P776 Biological effects of hyaluronan (HA): what to consider in HA-based biomaterial development
Kristina Nesporova, Barbora Safrankova, Vladimir Velebny

P777 Surface modification of pancreatic islets using tissue-adhesive polydopamine-coated poly(lactic-co-glycolic acid) microspheres for local drug delivery
Tiep Nguyen Tien, Tung Pham Thanh, Shiva Pathak, Shobha Regmi, Dong Ho Ha, Chul Soon Yong, Jong Oh Kim, Jee-Heon Jeong

P778 Influence of the secretome of adipose-derived stem cells on M1 macrophages in vitro
Anders Vendelbo Tomra, Fadumo Abdullahi Mohamed, Cansu Yener, Vladimir Zachar, Cristian Pablo Pennisi

P779 Surface-engineering of pancreatic islets with immunosuppressant loaded PEGylated polymeric nanoparticles as a novel strategy toward improving survival time of xenografted islets
Tung Pham Thanh, Tiep Nguyen Tien, Shiva Pathak, Shobha Regmi, Dong Ho Ha, Jong Oh Kim, Chul Soon Yong, Jee-Heon Jeong

P780 The role of interleukin-6 and nuclear factor kappa beta one in MSC-osteoclast-crosstalk in an in-vitro co-culture model for osteogenesis
Thomas Randau, Caecilia Hilgers, Hendrik Kohlhof, Max Friedrich, Matthias Wimmer, Sascha Gravius, Dieter Christian Wirtz, El Mustapha Haddouti

P781 Has a pure low molecular weight hyaluronan got the ability to activate immune response in mouse macrophages?
Barbora Safrankova, Vladimir Velebny

P782 Cultivation of immune cells in HA/GTN-based hydrogels
Ivana Scigalkova, Julie Bystronova, Martin Pravda, Nihal Engin Vrana, Toomas Neuman, Urmas Liivas, Vladimir Velebny

P783 Immunoregulatory and anti-microbial Cystapep 1 peptidomimetic - novel strategies of drug design to promote wound healing
Anna Wardowska, Milena Deptula, Maria Smuzynska, Paulina Langa, Jacek Zielinski, Franciszek Kasprzykowski, Sylwia Rodziewicz-Motowidlo, Michal Pikula

P784 Therapeutic effect of allogeneic bone marrow-derived MSCs for aortic aneurysm
Aika Yamawaki-Ogata, Naohiro Akita, Yuji Narita, Akihiko Usui, Kinihiro Komori

P785 TNF-ALPHA as the regulator of imflammation-induced activity of adipose tissue derived mesenchimal stem cells
Ekaterina Zubkova, Irina Beloglazova, Eugenie Shevchenko, Yelena Parfyonova, Mikhail Menshikov

Injectable scaffolds

P787 Assessment of injectable myocardial matrix derived from decellularized bovine cardiac tissue for mesenchymal stem cell culture
Hatice Ercan, A Eser Elcin, Y Murat Elcin

P788 A cost-effective method of (atelo)collagen type 1/3 (COL1/3) isolation from human placenta and its in vitro characterization in 2D and 3D cell culture applications
Johannes Hackethal, Severin Mühleder, Alexandra Hofer, Karl Heinrich Schneider, Johanna Prüller, Simone Hennerbichler, Johann Eibl, Heinz Redl, Andreas Teuschl

P789 Injectable hydrogel- PolyHIPE composite biomaterials for cartilage regeneration
Mohammed Hamazi, Neil Cameron

P790 In vitro and in vivo comparison of nanoparticular hydroxyapatite pastes of different particle content and size
Veronika Hruschka, Stefan Tangl, Yulia Ryabenkova, Abigail Pinnock, Aileen Crawford, Patrick Heimel, Dirk Barnewitz, Günter Möbus, Claudia Keibl, James Ferguson, Paulo Quadros, Cheryl Miller, Rebecca Goodchild, Wayne Austin, Heinz Redl, Thomas Nau

P791 Fabrication of visible marker on decellularized tissue for ultrasonography via reactive sputtering
Naruki Kimura, Yoshihide Hashimoto, Seiichi Funamoto, Akio Kishida, Yongwei Zhang, Akitatsu Yamashita, Kei Oya, Takeo Nakano

P792 A novel micro-fibrillar hybrid injectable biomaterial for vocal fold tissue engineering
Neda Latifi, Meisam Asgari, Luc Mongeau

P793 A minimal invasive injectable hybrid hydrogel that provides linear support for oriented nerve growth
Abdolrahman Omidinia-Anarkoli, Sarah Boesveld, Urandelger Tuvshindorj, Tamás Haraszti, Laura De Laporte

P794 Manufacturing porous microspheres which successfully support bone formation and stimulate an increased vascularisation response
Thomas Paterson, Colin Sherborne, Giulia Gigliobianco, Sheila MacNeil, Gwendolen Reilly, Frederik Claeyssens

Integrated enabling technologies for personalised regenerative medicine

P795 A new culture platform for cost-efficient adherent cell expansion
Ruud Das, Rens Roosloot, Wendy Tra, Marijn Driessen, Joost de Bruijn

P796 Introducing the SkinCreator – make bioengineered skin available for everyone – a Skintegrity Zurich project
Stephan C Fox, Thomas Biedermann, Marianne Schmid Daners, Ernst Reichmann, Mirko Meboldt

P797 Morphology-based real-time evaluation of culture condition
Masaya Fujitani, Shun Kawai, Kei Kanie, Ryuji Kato

P798 Application and understanding of morphological data for non-invasive quality control of stem cell manufacturing
Ryuji Kato

P799 Imaging regeneration after stem cell application for skeletal muscle reconstruction using diffusion tensor imaging (DTI) and magnetisation transfer (MT) measurements
Daniel Keller, Christian Eberhardt, Markus Rottmar, Deana Haralampieva, Andreas Boss, Daniel Eberli

P801 Personalized cement augmentation of the proximal femur using a discrete cement diffusion model
Sameuel Jesus Ramos Infante, Maria Angeles Perez Anson

P802 Integrating computational modelling with biofabrication to design and fabricate successful bone tissue engineering strategies
Aurélie Carlier, Gözde Akdeniz Skvortsov, Bahattin Koç, Liesbet Geris, Hans Van Oosterwyck

Nature as a source of TERM biomaterials and strategies

P803 Engineering of an osteo-inductive decellularized extracellular matrix using an immortalized human cell line
Fabiana Gullotta, Thibaut Klein, Paul Bourgine, Sebastien Pigeot, Attilio Bondanza, Ivan Martin

P804 Detergent-based decellularization strategy well-preserves macro- and microstructure of pulmonary heart valves
Jessica Haupt, Alina Paur, Jette Seiler, Stanislav Gorb, Dan Simionescu, Georg Lutter, Irma Haben

P805 Comparison between zebrafish- and human-derived decellularized extracellular matrix (ECM) for the cell culture
Kwang-Hun Jeong, Ruth Eggers, In-Hyuk Baek, Youngjun Kim

P807 Successful decellularization of thick-walled tissue - a multifactorial approach
Marie-Cristin Kilzer, Nikolaus Thierfelder, Christian Hagl, Fabian König

P808 Auxetic materials in tissue engineering
Jordan Roe, Prasad Godbole, Nicola Jordan-Mahy, Andrew Alderson, Christine Le Maitre

P809 Calcium phosphate scaffolds with high specific surface area towards improved cell response in vitro
Janis Locs, Jana Vecstaudza

P810 Omega-7 accelerates healing of grafted skin burn wounds
Yosuke Niimi, Perez-Bello Dannelys, Satoshi Fukuda, Koji Ihara, Jisoo Kim, Robert A Cox, Hal K Hawkins, David Herndon, Donald S Prough, Perenlei Enkhbaatar

P811 Evaluation of a novel detergent-based method for decellularization of peripheral nerve allografts
Charlot Philips, Fernando Campos, Annelies Roosens, Maria Cornelissen, Victor Carriel

P812 Exploring macrophage interactions with zwitterionic hydrogels
Xiao-Hua Qin, Vera Malheiro, Markus Rottmar, Katharina Maniura-Weber

P813 A novel approach for the synthesis and fabrication of naturally derived biocompatible β-TCP scaffolds through mechanical stimulation
Uday Kiran Roopavath, Mahesh Kumar Sah, Subha Narayan Rath

P814 Keratins from Human Hair and Wool: isolation, characterisation and gel formation studies
Hongyun Tai, David Mondragon De La Cruz, Alan Hughes, Sigen A, Charles Antubam Ben-Cofie, Wenxin Wang

P815 The human amniotic membrane's metabolic landscape
Asmita Banerjee, Adelheid Weidinger, Andrea Lindenmair, Simone Hennerbichler, Johann Eibl, Andrey Kozlov, Heinz Redl, Susanne Wolbank

P816 Mimicking the structure of fracture hematomas using snake venom enzymes for the creation of an ex vivo natural designer scaffold to enhance bone repair
Vaida Glatt, Thor Friis, Anna Woloszyk, Paul Masci, Kevin Tetsworth

P818 Screening of anabolic and anti-inflammatory effect of biological small molecules for treatment of osteoarthritis
Rihane Ziadlou, Sibylle Grad, Martin J Stoddart, Andrea Barbero, Ivan Martin, Mauro Alini

New advancements in drug-free antibacterial biomaterials for medical applications

P819 Surface functionalization of chemically treated Ti6Al4V alloy with mentha piperita essential oil
Martina Cazzola, Sara Ferraris, Valeria Allizond, Giuliana Banche, Cinzia Margherita Bertea, Silvia Spriano

P820 Bioactive and antibacterial Ti6Al4V for bone contact applications
Martina Cazzola, Sara Ferraris, Valeria Allizond, Giuliana Banche, Grzegorz Cempura, Aleksandra Czyrska-Filemonowicz, Silvia Spriano

P821 Biosurfactant-based coatings inhibit fungal and bacterial biofilm on medical-grade silicone
Chiara Ceresa, Francesca Ruini, Maurizio Rinaldi, Francesco Tessarolo, Devid Maniglio, Giandomenico Nollo, Iole Caola, Gianna Allegrone, Valeria Chiono, Letizia Fracchia

P822 Three-dimensional human skin wound infection equivalent as a tool for bioanalysis of antimicrobial polymeric biomaterials for wound dressings
Ayesha Idrees, Sandra Pacharra, Richard Viebahn, Gianluca Ciardelli, Valeria Chiono, Jochen Salber

P823 Development of biomass-based carbon composites as an anti-microbial wound dressing material
Young-Gwang Ko, Seo Hee Han, Soohyeon Jeon, Jiyoung Lee, Donghwan Cho, Won Ho Park, Oh Hyeong Kwon

P824 Medical-grade silicone coated by AC7 biosurfactant inhibits fungal biofilm formation preserving biocompatibility
Francesco Tessarolo, Chiara Ceresa, Devid Maniglio, Federico Piccoli, Sabrina Eccheli, Maurizio Rinaldi, Gianna Allegrone, Francesca Ruini, Valeria Chiono, Giandomenico Nollo, Iole Caola, Letizia Fracchia

P825 Novel natural polymers with antibacterial properties
Elena Marcello, Pooja Basnett, Ipsita Roy

P826 Dual-action fluorophosphonate titanium coatings to reduce bacterial adherence and encourage osseointegration
Wayne Nishio Ayre, Tom Scott, Keith Hallam, Ashley Blom, Stephen Denyer, Jason Mansell

P827 Metal and polymeric components with antibacterial surfaces fabricated via ultra-short pulsed laser ablation and thermal processing technologies
Rocio Ortiz, Jose Antonio García-Lorente, Iban Quintana

P828 Surface functionalization strategies to inhibit biofilm formation on silicone materials for implantable devices
Francesca Ruini, Chiara Ceresa, Gianna Allegrone, Devid Maniglio, Federico Piccoli, Maurizio Rinaldi, Giandomenico Nollo, Iole Caola, Francesco Tessarolo, Letizia Fracchia, Gianluca Ciardelli, Valeria Chiono

P829 Antibacterial chitosan nanoparticles for a tissue-engineered brain patch
Sakshi Shah, Zachary Shattler

P830 Chondrogenesis-inductive nanofibrous substrate biofunctionalized with autologous growth factors from platelet lysates for stem cell based therapies
Marta Casanova, Marta Alves da Silva, Ana Rita Costa-Pinto, Rui Luis Reis, Albino Martins, Nuno M Neves

P832 Attenuation of human MSC hypertrophy in 3D culture via treatment with a retinoic acid receptor inverse agonist
Moritz HA Riedl, Girish Pattappa, Michael Nerlich, Peter Angele, Denitsa Docheva, Michael B Müller, Robert L Mauck, Christian G Pfeifer

Peripheral Nerve Regeneration- towards clinical translation

P834 A novel multi-layered and mono-fascicled nerve substitute. An in vitro and in vivo characterization study
Victor Carriel, Fernando Campos, Miguel-Angel Martin-Piedra, Olga Roda, Majed Jouma Katati, Esther Miralles, Jose-Antonio Saez-Moreno, Maria Cornelissen, Antonio Campos

P835 Generation and ex vivo characterization of crosslinked fibrin-agarose hydrogels for neural tissue engineering
Fernando Campos, Ana B Bonhome, Daniel Durand-Herrera, Boris D Jaimes-Parra, Modesto T Lopez-Lopez, Miguel Alaminos, M Carmen Sanchez-Quevedo, Miguel A Martin-Piedra, Victor Carriel

P837 Mathematical model of a nerve guidance conduit combining physical and chemical gradients
Celine Kayal, Rebecca Shipley, James Phillips

P840 Development of aligned endothelial cells in collagen gels to promote nerve regeneration
Papon Muangsanit, James Phillips, Alison Lloyd

P841 In vitro, ex vivo and in vivo analysis of novel 3D printed PGSm nerve guidance conduits for peripheral nerve repair
Dharaminder Singh, Emad Albadawi, Adam Harding, Fiona Boissonade, Frederik Claeyssens

P842 Investigating the use of engineered neural tissue to generate peripheral nerve repair constructs populated with neurons
Titinun Suannun, Jonathan Knowles, James Phillips

P843 Interleukin-6 conjugated chitosan scaffolds for promoting peripheral nerve regeneration
Xin Tang, Yahong Zhao, Yumin Yang

P844 Development of acellular allogeneic nerve grafts for peripheral nerve reconstruction
GE Webster, JDR Holland, RM Hall, P Rooney, S-P Wilshaw

Regenerative Immunology

P845 A novel, versatile method for the development of immunomodulatory synthetic grafts for in situ vascular tissue regeneration
Valentina Bonito, Anita Driessen Mol, TJAG Munker, OJGM Goor, AW Bosman, Tristan Mes, PYW Dankers, AIPM Smits, CVC Bouten

P846 The bone healing process benefits from a naïve immune cell milieu - a humanized mouse model study
Christian H Bucher, Claudia Schlundt, Hans-Dieter Volk, Georg N Duda, Katharina Schmidt-Bleek

P847 Reconstruction of mandibular bone with the contribution of Gelpord3D constructs in pig
Miguel A Ortega, Alejandro Coca, Sergio Peña, J Peña, MV Cabañas, Julio San Román, Robert Mecham, Julia Buján, Natalio García-Honduvilla

Spine, the backbone of translational medicine

P849 Anabolic effects of bioactive proteins and extracellular vesicles derived from notochordal cell-conditioned medium
Frances Bach, Stefan de Vries, Frank Riemers, Janneke Boere, Ferdi van Heel, Marina van Doeselaar, Soenita Goerdayal, Peter Nikkels, Karin Benz, Laura Creemers, Maarten Altelaar, Björn Meij, Keita Ito, Marianna Tryfonidou

P850 The regenerative effects of notochordal cell matrix on nucleus pulposus cells
Frances Bach, Anna Tellegen, Stefan de Vries, Martijn Beukers, Laura Creemers, Björn Meij, Keita Ito, Marianna Tryfonidou

P851 Combining engineered silk composite and genipin-enhanced fibrin hydrogel to repair the annulus fibrosus
Daniela A Frauchiger, Adel Tekari, Michael Wöltje, Lorin M Benneker, Benjamin Gantenbein

P852 Glucose uptake of human intervertebral disc cells in 3d culture monitored in real-time
Daniela A Frauchiger, Rahel D May, Andreas K Koch, Lorin M Benneker, Benjamin Gantenbein

P855 The therapeutic effect of human bone marrow-derived clonal mesenchymal stem cells on scar formation in spinal cord injury
Kil Hwan Kim, Moonhang Kim, Sun U Song, Tac Ghee Yi, Seung Hwan Yoon, So Ra Park, Byung Hyune Choi

P858 Effect of exogenous stimulation of the BMP antagonists Gremlin and Noggin on primary human osteoblasts and mesenchymal stem cells
Rahel May, Daniela Frauchiger, Adel Tekari, Sandro Kohl, Lorin Benneker, Benjamin Gantenbein

P859 Formation of calcium deposits in primary human osteoblasts in the presence of intervertebral disc cells
Rahel May, Daniela Frauchiger, Adel Tekari, Lorin Benneker, Sandro Kohl, Benjamin Gantenbein

P860 ntradiscal application of a pcla-peg-pcla hydrogel loaded with celecoxib for the treatment of back pain: A translational approach
Anna Tellegen, Nicole Willems, Martijn Beukers, Guy Grinwis, Saskia Plomp, Mike De Leeuw, Maarten Van Dijk, Laura Creemers, Marianna Tryfonidou, Björn Meij

P861 Novel knitted titanium nucleus implant: potential role for tissue engineering
Gauri Tendulkar, Vrinda Sreekumar, Sabrina Ehnert, Alfred Buck Sen, Alfred Buck Jun, Hans-Peter Kaps, Ashok Kumar, Andreas Nüssler

P862 Decellularized ECM coated microparticles release neurotrophic factors to support dental stem cells differentiation for spinal cord regeneration
Aiswarya Viswanath, Jasmine Stening, Lalitha Thiagarajan, David Scurr, Kevin Shakesheff, Anne des Rieux, Lisa White

Stem cell culture and differentiation on biomaterials

P863 Generation of a bioengineered substitute of the human ureter using transdifferentiated cells and nanostructured biomaterials
Boris D Jaimes-Parra, Victor Carriel, Fernando Campos, Miguel-Angel Martin-Piedra, Miguel Alaminos, Jose-Manuel Garcia, Pascual-Vicente Crespo, Antonio Campos, Ingrid Garzon, Ricardo Fernandez-Valades

P864 Immunohistochemical identification of major histocompatibility complex antigens in transdifferentiated epithelial cells
Ingrid Garzon, Miguel-Angel Martin-Piedra, Maria del Carmen Sanchez-Quevedo, Fernando Campos, Alejandro Vela-Romera, Victor Carriel, Ismael-Angel Rodriguez, Victor Ruiz, Miguel Alaminos, Ricardo Fernandez-Valades

P865 Formation of libraries of chemically functionalised and topographically textured microparticles to screen stem cell-particle interactions
Marta Alvarez-Paino, Kevin Shakesheff, Morgan R Alexander, Cameron Alexander, David Needham, Felicity RAJ Rose

P866 Effect of substrate topography on osteogenic potential of mouse iPS-cell derived embryoid bodies out growing cells
Akram Al-Wahabi, Tungalag Ser-Od, Kenji Inoue, Kei Nakajima, Reiko Tokita, Kenichi Matsuzaka, Takashi Inoue

P867 A comparative study of human plasma fibronectin potentialization of the osteogenic activity of BMPs (-2, -6 and -7) onto hydroxyapatite coatings
Isabelle Brigaud, Rémy Agniel, Johanne Leroy-Dudal, Sabrina Kellouche, Arnaud Ponche, Tahar Bouceba, Felix Sima, Ion Mihailescu, Ana Claudia Carreiras, Mari Cleide Sogayar, Olivier Gallet, Karine Anselme

P868 Modulation of gene expression in human adipose-derived stem cells seeded on PLGA or biomimetic nanocomposite: comparison of 2D films and 3D electrospun meshes - the real comparison
Samuel Hess, Wendelin Stark, Sonja Märsmann, Pietro Giovanoli, Paolo Cinelli, Johanna Buschmann

P869 Human pluripotent stem cells cultured on recombinant human vitronectin-grafted hydrogels by adjusting surface charge
Li-Hua Chen, Hsing-Fen Li, Akon Higuchi

P870 Pore alignment regulates MSC differentiation in solubilized extracellular matrix derived scaffolds
Pedro J Díaz-Payno, Dave C Browe, Daniel J Kelly

P871 Myocardial differentiation of human adipose stem cells on elastin surfaces
Arin Dogan, A Eser Elcin, Y Murat Elcin

P873 Cellularization of an esophagus substitute by hADSC sheets
Guillaume Charles, Guillaume Luc, Samantha Roques, Mallory Meulle, Lionel Couraud, Reine Bareille, Denis Collet, Laurence Bordenave, Marlène Durand

P874 Investigating the alignment of cellulose nanowhiskers and its potential to encourage myogenic differentiation of stem cells
Annchalee Eade

P875 MicroRNA expression of osteogenically differentiated human adipose stem cells under hypoxic and normoxic culture conditions
A Eser Elcin, Oya Celikag, Y Murat Elcin

P877 Platelet-rich plasma modulates mesenchymal cells chondrogenesis in collagen-hyaluronic acid scaffolds according to concentration
Ronaldo JFC do Amaral, Amos Matsiko, Marcel RP Tomazette, Eric Cordeiro-Spinetti, Tanya J Levingstone, Marcos Farina, Fergal J O'Brien, Marcia C El-Cheikh, Alex Balduino

P878 Growth and differentiation of adipose-derived stem cells on Ti-doped diamond-like carbon layers
Elena Filova, Martina Travnickova, Miroslav Jelinek, Tomas Kocourek, Petr Slepicka, Lucie Bacakova

P879 Pluripotency and differentiation ability of human adipose-derived stem cells cultured in 2D and 3D culture
Chao-Wen Hsieh, Akon Higuchi, Hsing-­Fen Li

P880 In situ and in vivo monitoring of biological response to titanium dental implant through measuring electrochemical parameters
Ying-Sui Sun, Her-Hsiung Huang

P882 The effect of degradation of ternary composite scaffolds on differentiation of human bone marrow mesenchymal stem cells
Joanna Idaszek, Jan E Brinchmann, Wojciech Święszkowski

P883 Direct reprogramming of fibroblasts into integration-free, induced neurons using mRNA delivery
Byung Soo Kim, Jong Pil Kim, Ssang Goo Cho, Soon Bong Paek, Jaesur Oh, Juhyung Song, Mikyung Kang, Hwan Choi, JunSang Yoo, Hongwon Kim

P884 Characterization of clonal colony formation process of human induced pluripotent stem cells based on kinetic analysis
Meehae Kim, Nobuhiko Kondo, Mashiro Kino-Oka

P885 Gelatin based biocoposite film for in vitro development of respiratory epithelium
Pramod Kumar, Nihal Vrana, Amir Ghaemmaghami

P886 The design and production of chemical nanoarrays to control mesenchymal stem cell adhesion and differentiation using polymer pen lithography
I-Ning Lee, Lu Shin Wong, John A Hunt, Judith M Curran

P887 Mesenchymal stem cells for osteonecrosis of the femoral headdata from ongoing clinical trial (code: xcel-mt-10-01; eudract: 2010-023998-18)
Alba López-Fernández, Roberto Vélez, Alejandro Hernández-Martínez, Ruth Coll, Joaquim Vives, Joan Garcia, Màrius Aguirre

P888 Biological characterization of phosphate-based glass microspheres for stem cell culture and differentiation
Laura Macri-Pellizzeri, Kazi M Zakir Hossain, Nigel De Melo, Md Towhidul Islam, Caitriona McCarron, David Grant, Brigitte Scammell, Ifty Ahmed, Virginie Sottile

P890 Design and in vitro testing of a biofunctionalised polycaprolactone nanofibrous scaffold capable of recruiting endothelial progenitor cells
Isra Marei, Yuan-Tsan Tseng, Jerome Sohier, Matthias Gabriel, Najma Latif, Magdi Yacoub, Jane Mitchell, Adrian Chester

P891 Investigating the fate and location of therapeutic magnetic nanoparticle tagged stem cells post implantation in an ovine critical sized defect model
Hareklea Markides, Jane McLaren, Brigitte Scammell, Kevin Shakesheff, Alicia El Haj

P894 Effect of hyaluronan supplemented culture media on human mesenchymal stem cell chondrogenesis
Graziana Monaco, Niamh Fahy, Mauro Alini, Martin Stoddart

P895 Deciphering osteogenic differentiation of bone progenitor cells on novel dental implant surfaces
Eike Müller, Markus Rottmar, Stefanie Guimond, Ursina Tobler, Marc Stephan, Simon Berner, Katharina Maniura

P897 Matrix interactions controlling osteogenesis from pluripotent stem cells
Raha Osilan, Agamemnon Grigoriadis, Eileen Gentleman

P898 Investigating co-culture of periosteal and bone marrow mesenchymal stem cells onto bone scaffolds for critical size bone defect repair
Heather Owston, Elena Jones, Peter Giannoudis, Stephen Russell, Giuseppe Tronci

P899 In vitro differentiation of rat omentum-derived mesenchymal stem cells into parathyroid-like cells for the treatment of permanent hypoparathyroidism
Ki Nam Park, Yunhye Kim, Yong Sung Hwang, Young-Ik Son, Jae Hong Park, Soo Yeon Jung, Hae Sang Park, Yoo Seob Shin, Won Shik Kim

P900 The effect of osteogenesis on scaffolds fabricated using melt electrospinning writing using a co-culture model
Patrina SP Poh, Carlos Diaz Cano, Elena De Juan Pardo, Martijn van Griensven

P901 Osteoconductive scaffolds based on bioactive polysaccharides for the proliferation of human derived dental pulp stem cells
Davide Porrelli, Federica Vecchies, Francesco Brun, Eleonora Marsich, Sergio Paoletti, Gianluca Turco

P903 Suitability of human muscle-derived stem cells on electrospun PCL scaffolds for skeletal muscle tissue engineering
Sowmya Ramesh, Sanjana Ravindran, David Livingstone, Vrisha Madhuri

P904 Hybrid assemblage of gingiva-derived mesenchymal stem cells and nitric oxide releasing microsphere for enhanced differentiation
Shobha Regmi, Shiva Pathak, Dong-Ho Ha, Tung Thanh Pham, Tiep Tien Nguyen, Jong Oh Kim, Chul Soon Yong, Jee-Heon Jeong

P905 Viability of synovial fluid MSCs cultured on electrospun PCL membranes containing microfabricated features
Martin Eduardo Santocildes-Romero, Saima Ahmed, Aileen Crawford, Paul Hatton, Ilida Ortega

P907 A novel real-time migration assay identifies stem cell migration in 3D matrices
Kavitha Sivasubramaniyan, Gert-Jan Kremers, Mariana Cruz, Edi Tanase, Ruth E Cameron, Serena M Best, Martin van Royen, Gerjo JVM van Osch

P909 3D matrices based on collagen I and low-sulfated hyaluronan are promising biomaterials supporting bone regeneration
Sarah Vogel, Franziska Ullm, Tilo Pompe, Ute Hempel

P910 Development of completely defined media for hASC-based adipose tissue setup
Ann-Cathrin Volz, Svenja Nellinger, Petra Kluger

TERM in Ophthalmology

P912 Umbilical cord wharton's jelly stem cells transdifferentiation to cornea epithelium. A histological and immunohistochemical study
Ingrid Garzon, Victor Carriel, Fernando Campos, Miguel-Angel Martin-Piedra, Carmen Gonzalez-Gallardo, Jose-Ignacio Muñoz-Avila, Santiago Medialdea, Antonio Campos, Miguel Alaminos

P913 The human tissue-engineered cornea as a model to study the impact of altering the activity of CREB and AKT during corneal wound healing
Camille Couture, Pascale Desjardins, Karine Zaniolo, Lucie Germain, Sylvain Guérin

P914 Impact of pharmacological alteration of integrin-dependent signalling pathways on corneal wound healing using a human tissue-engineered cornea as a model
Pascale Desjardins, Camille Couture, Karine Zaniolo, Sylvain Guérin, Lucie Germain

P915 Cornea endothelium differentiation of human umbilical cord, adipose tissue and dental pulp stem cells. A comparative gene expression study
Ingrid Garzon, Miguel-Angel Martin-Piedra, Fernando Campos, Miguel Gonzalez-Andrades, Laura Rico, Victor Carriel, Gerson Vizcaino, Antonio Campos, Miguel Alaminos

P916 Deriving an in vitro source of canine corneal stromal stem-like cells to use as potential source for novel treatment strategy for blinding corneal disease
Christiane Kafarnik

P917 Contribution of the transcription factors Sp1 and NFI to the preservation of stem cells in tissue-engineered human corneas
Gaëtan Le-Bel, Karine Zaniolo, Francis Bisson, Sylvain Guérin, Lucie Germain

P918 Influence of material stiffness on corneal epithelial cell behaviour
Sophia Masterton, Mark Ahearne

P919 Development of a human, 3D, ophthalmic cell culture model for regenerative medicine and drug delivery
Sara Shafaie, Victoria Hutter, Marc Brown, Michael Cook, David Chau

P920 Developing corneal stromal stem cell sheets from an amniotic membrane protein bio-functionalized thermos-responsive polymer substrate for corneal surface therapies
Balu Venugopal, Laura Sidney, Anil Kumar PR, Andrew Hopkinson, Kumary TV

Tissue engineering borders cellular therapies

P923 High-throughput development and analysis of prevascularized spheroids for therapeutic cell delivery
Daniel Carvalho, Ewa Bauman, Tália Feijão, Cristina Barrias

P924 Bespoke full-thickness skin as a permanent graft solution
Elliott Dunn, Vaughan Feisst, Inken Kelch, Michelle Locke, Rod Dunbar

P925 Surveying cellular and engineered tissue therapies in europe and associated countries in 2014 and 2015
Max H-P Gay, Hilary Ireland, Helen Baldomero, Massimo Dominici, Jakob Passweg, Ivan Martin

P926 Recombinant human collagen type I hydrogels as superior cell carriers for corneal epithelial stem cells
Michel Haagdorens, Eline Melsbach, Ramunas Valiokas, Vytautas Cepla, Vygandas Juras, Amit Yaari, Oded Shoseyov, Monika Ljuggren, Nadav Orr, Yehiel Tal, Marie-José Tassignon, May Griffith, Nadia Zakaria

P927 Artificial hypoxia inducible factor-1α (HIF-1α) stabilization enhances cell survival in 2D & 3D models
Wai Ho, Barry Fuller, Gavin Jell

P928 Feasibility of plasma gel as injectable scaffold for hypoparathyroidism cell therapeutics using tonsil-derived mesenchymal stem cells
Soo Yeon Jung, Han Su Kim, Ha Yeong Kim, Hae Sang Park, Hyun Ju Oh

P930 Optimizing mesenchymal stromal cell therapy using a si-HPMC hydrogel and RGTA molecule for the treatment of severe side effects of pelvic radiotherapy
Lara Moussa, Girish Pattappa, Christelle Demarquay, Fernando Sineriz, Jérôme Guicheux, Pierre Weiss, Gildas Réthoré, Denis Barritault, Noëlle Mathieu

P931 A new tool for direct read-out of transcription factor activity in live cells
Kannan Govindaraj, Marcel Karperien, Janine Post

P932 Role of primary blood outgrow endothelial cells on the revascularization of decellularized porcine organs with a chemically-defined medium in a dynamic perfusion biorreactor
Miguel Rodrigues, Gudrun Dandekar, Joris Braspenning, Heike Walles

P933 Tissue-engineered vascular patches prepared from nanofilms and endothelial cells derived from induced pluripotent stem cells
Susana Rosa, Pedro Gouveia, Leonardo Ricotti, Ariana Menciassi, Lino Ferreira

P934 Human cardiac extracellular matrix coating improves the bioactivity of scaffolds designed to support myocardial regeneration processes
Matthias Becker, Maria Schneider, Janita Maring, Martina Seifert, Nan Ma, Wing Tai Tung, Volkmar Falk, Christof Stamm

Veterinary regenerative medicine animal models and clinical patients

P938 Modelling muscle disease in the horse using induced plurpotent stem cells
Karin Amilon, Ben Moore, Simon Lillico, Xavier Donadeu

P939 Porous hydroxyapatite scaffold for bone regeneration in canine alveolar sockets
Seok Jin Jang, Jun Sik Son, Seong Soo Kang, Gonhyung Kim, Seok Hwa Choi

P940 Phlorotannin/Polycaprolactone coated endotracheal tube to prevent thracheal stenosis
Min-Seon Jeong, Hyoung-Shin Lee, Seok-Chun Ko, Sung-Won Kim, Kang-Dae Lee, Chul-Ho Ok, Won-Kyo Jung

P941 The transpedicular surgical approach for the development of intervertebral disc targeting regenerative strategies in an ovine model
Luc Le Fournier, Marion Fusellier, Boris Halgand, Julie Lesoeur, Olivier Gauthier, Philippe Menei, Claudia Montero-Menei, Jérôme Guicheux, Johann Clouet

P942 Development of a canine intestinal organoid model
Andre Meneses, Bart Spee, Loes Oosterhoff, Manabu Sakai, Kerstin Schneeberger, Louis Penning, Iwan Burgener

P943 The release of titanium and zirconium in mini pig maxillae from titanium-implants and zirconia implants
Xiuli He, Stefan Milz, Bernhard Michalke, Christoph Martin Sprecher, Michael Gahlert, Stefan Röhling, Heinz Kniha, Christof Hoegg, Franz-Xaver Reich

P944 Non-union defects show impaired bone formation in the early reparative phase in mouse femoral defect models
Esther Wehrle, Duncan Betts, Gisela Kuhn, Ariane Scheuren, Sandra Hofmann, Ralph Müller

Poster Abstracts ALL POSTER ABSTRACTS (one file)